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Diss Factsheets
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EC number: 939-689-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-aminoethanol
- EC Number:
- 205-483-3
- EC Name:
- 2-aminoethanol
- Cas Number:
- 141-43-5
- IUPAC Name:
- 2-aminoethanol
- Details on test material:
- - Name of test material: Monoethanolamine (2-Aminoethanol)
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 1.0, 2.0 or 4.0 mL/kg bw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for toxicity and skin reactions were made at 1 hour, 7 days and 14 days after the contact period. Animal weights were recorded at 0 (before dose), 7 and 14 days (just prior to termination).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopical examination
Groups of 5 animals/sex (2-3 kg) were subjected to 24 hours of contact with the test item (1.0, 2.0 or 4.0 mL/kg bw) which was retained under impervious sheeting on the clipped, intact skin of the trunk. As necessary for larger doses, gauze was wrapped around the trunk over the sample to prevent leakage. Bandaging tape was wrapped over the impervious sheeting and the animal was returned to its cage for the contact period. Doses were varied by adjusting the volume of the test material. After the contact period, excess fluid was removed to diminish ingestion. At death or termination, each animal was subjected to a gross pathologic evaluation. - Statistics:
- LD50 values and the estimated LD50 slopes were calculated by the moving average method (Thompson, 1947; Weil, 1983).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2.46 - <= 2.83 mL/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 504 mg/kg bw
- 95% CL:
- 1 822 - 3 451
- Remarks on result:
- other: slope: 5.60
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 881 mg/kg bw
- 95% CL:
- 1 639 - 5 070
- Remarks on result:
- other: slope: 3.89
- Mortality:
- The mortality incidences were as follows:
4.0 mL/kg bw: 9/10 rabbits (5 males, 4 females; at 1-2 days)
2.0 mL/kg bw: 2/10 rabbts (1 male, 1 female; at 2 days, at 13 days)
1.0 mL/kg bw: 0/10 rabbits (0 male, 0 female; N/A)
Deaths occurred within two days, except for one female rabbit that died at 13 days. - Clinical signs:
- other: MALES 4.0 mL/kg bw erythema, edema, necrosis, ecchymosis at 1 day; prostration in 1 animal at 1 day
- Gross pathology:
- MALES
4.0 mL/kg bw
lungs salmon-colored; trachea of 1 animal dark red; thymus of 1 animal mottled dark red; large intestines of 1 animal hemorrhaged
2.0 mL/kg bw
in deceased animal, lungs mottled salmon-colored and bright red; in survivors, lungs bright pink, salmon-colored or mottled bright pink to dark red
1.0 mL/kg bw
lungs of 1 animal dark red
FEMALES
4.0 mL/kg bw
in deceased animals, lungs salmon-colored to dark red, with dark red foci, thymus of 1 animal dark red, intestines hemorrhaged; in survivor, nothing remarkable.
2.0 mL/kg bw
in deceased animal, stomach, intestines liquid and gas-filled, small intestines hemorrhaged; in survivors, lungs salmon-colored to red, kidneys of 1 animal with a pitted surface, intestines of 1 animal gas-filled
1.0 mL/kg bw
lungs salmon-colored to dark red, 1 animal with dark red foci, stomachs and intestines of 2 animals liquid and/or gas-filled, small intestines of 1 animal hemorrhaged, abdominal cavity of 1 animal liquid-filled
Any other information on results incl. tables
The LD50 value for males was 2.46 mL/kg bw (2504 mg/kg bw) with a 95 % confidence level of 1.79-3.39 mL/kg bw (1822-3451 mg/kg bw) and a slope of 5.60. The LD50 value for females was 2.83 mL/kg bw (2881 mg/kg bw) with a 95 % confidence level of 1.61 - 4.98 mL/kg bw (1639-5070 mg/kg bw) and a slope of 3.89.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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