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EC number: 212-091-6 | CAS number: 762-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: similar to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Male and female Wistar rats were shaved prior to dermal treatment with test substance in cellulose for 24 hours. The treated area was covered with bandage round back and belly. After removing of the bandage the treated area was washed with soap and water . the post exposure observation time was 14 days,animals were observed for skin effects, clinical signs and mortality. The LD50 was calculated according to Lichtfield and Wilcoxon, 1949
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl phosphonate
- EC Number:
- 212-091-6
- EC Name:
- Diethyl phosphonate
- Cas Number:
- 762-04-9
- Molecular formula:
- C4H11O3P
- IUPAC Name:
- diethyl phosphonate
- Test material form:
- other: colourless liquid
- Details on test material:
- content not given
the substance is described as technically pur colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Fasting period before study: ca 16 hours
- Diet ad libitum:
- Water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no details given
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: cellulose
- Details on dermal exposure:
- Male and female Wistar rats were shaved prior to dermal treatment with test substance in cellulose for 24 hours. The treated area was covered with bandage round back and belly. After removing of the bandage the treated area was washed with soap and water . the post exposure observation time was 14 days,animals were observed for skin effects, clinical signs and mortality. The LD50 was calculated according to Lichtfield and Wilcoxon, 1949
- Duration of exposure:
- 24 hours
- Doses:
- 1000, 2500, 3500, 5000, 5500(females only), 6000, 6500 (males only) µl/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females , each group treated with 1000 and 2500 µl/kg bw, respectively
for all other doses: 10 males and 10 females - Control animals:
- no
- Details on study design:
- Male and female Wistar rats were shaved prior to dermal treatment with test substance in cellulose for 24 hours. The treated area was covered with bandage round back and belly. After removing of the bandage the treated area was washed with soap and water . the post exposure observation time was 14 days,animals were observed for skin effects, clinical signs and mortality. The LD50 was calculated according to Lichtfield and Wilcoxon, 1949
- Statistics:
- The LD50 was calculated according to Lichtfield and Wilcoxon, 1949
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 695 other: µl/kg bw
- 95% CL:
- >= 3 833 - <= 5 751
- Remarks on result:
- other: ca. 5071 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 850 other: µl/kg bw
- 95% CL:
- >= 4 170 - <= 5 641
- Remarks on result:
- other: ca. 5238 mg/kg bw
- Mortality:
- no rat died following treatment with 1000 and 2500 µl/kg bw
male:
3500 µl/kgbw: 1/10 within 5 days; 5000 µl/kgbw: 5/10 within 1-3 days
6000 µl/kgbw: 9/10 within 1-2 days; 6500 µl/kgbw: 10/10 within 1 day
female
3500 µl/kgbw:2/10 within 2-4 days; 5000 µl/kgbw:4/10 within 2 days
5500 µl/kgbw:7/10 within1-2days; 6500 µl/kgbw: 10/10 within 1-2 days - Clinical signs:
- other: males and females treated with 1000 µl/kg bw: showed no clinical signs all others:apathy, rough fur, prone position, sedation, reduced motility, accelerated breathing skin: the treated area was very strong irritated and necrotic , but during the post ex
- Gross pathology:
- animals that died during the observation period showed distended lungs, pale liver, kidneys and spleens with partly spotted surface
Applicant's summary and conclusion
- Executive summary:
Male and female Wistar rats were shaved prior to dermal treatment with test substance in cellulose for 24 hours. The treated area was covered with bandage round back and belly. After removing of the bandage the treated area was washed with soap and water . the post exposure observation time was 14 days,animals were observed for skin effects, clinical signs and mortality. The LD50 was calculated according to Lichtfield and Wilcoxon, 1949. The LD50(dermal, male rat) was 4695 µl/kg bw (ca.5071 mg/kg bw) and LD50 (dermal, female) 4850 µl//kg bw ca. (5238 mg/kg bw)
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