Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-367-9 | CAS number: 939-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
There is valid information available concerning the skin sensitization potential of p-tert-butylbenzaldehyde, however, no key study can be defined.
The sensitizing capacity of p-tert-butylbenzaldehyde was investigated in guinea pigs and also in human volunteers.
One of the experimental results demonstrates a negative result for p-tert-butylbenzaldehyde, in an open epicutaneous test using guinea pigs (3-4 animals/group). Induction was performed by repeated epicutaneous application (daily for 21 days) using 3, 10 or 30% p-tert-butylbenzaldehyde in ethanol or undiluted p-tert-butylbenzaldehyde. Challenge was performed using a 10% solution on the 21th and 35th day at 30 % (Givaudan 1980 OET). No skin sensitization reactions were observed in this test setup.
Another study (Freuds Complete Adjuvans Test) demonstrated as skin sensitizing potential of p-tert-butylbenzaldehyde. Following intradermal induction (0.1 ml 5 % emulsion in Freund's complete adjuvant on days 0, 2, 4, and 7), sensitizing effects were seen in 3/6 animals after the epicutaneous challenge on the 21st and 35th day at a concentration of 0.3 %, and in 6/6 animals at concentration of l, 3 and 10 % (Givaudan 1980 FCAT).
Concerning human studies, there is no evidence for sensitising capacity of the test substance. In a human repeated insult patch test, 51 volunteers received ten 24-hour occlusive applications of 2% p-tert-butylbenzaldehyde (about 200 mg) in dimethylphthalate over a period of three weeks (Givaundan 1979). After a resting period of 10 -14 days, a single occlusive dermal 24 hours challenge application (2% in dimethylphtalate) was performed. No dermal reactions were observed in the 51 volunteers, providing evidence for the absence of skin sensitizing properties under the chosen testing conditions.
Overall in a weight of evidence, p-tert-butylbenzaldehyde is considered to be a skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No information is available.
Migrated from Short description of key information:
No information is available
Justification for classification or non-classification
The present data on dermal sensitization fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC, and therefore, a classification with R43 and "Skin sensitisation" (Category 1) is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.