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Diss Factsheets
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EC number: 903-945-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No data on long-term toxicity to fish is available on the reaction mass of chlorodifluoroacetic acid (CDFA) and trifluoroacetic acid (TFA).
One reliable data is available on the main constituent of the reaction mass, i.e. CDFA. This study was performed according to the OECD testing guideline 204 “Fish, Prolonged Toxicity Test: 14-day Study” (1984) under semi-static conditions of 72 h-renewal. The threshold levels of lethal and other observed effects in fish (Brachydanio rerio) exposed to Chlorodifluoroacetic acid for 14 days were determined.
During the whole test period, the pH values of the control and Test Media were between 7.2 and 7.3, and the Dissolved Oxygen (DO) values varied from 88% to 99% of the air saturation at the test temperature, and the temperature of the Test Media was maintained in the range of 22°C to 23°C. All fishes in the control group were normal. So the study met the acceptability criteria.
For mortality, the NOEC was 40 mg/L (measured concentration 41.8 mg/L). No effect on behaviour, length and weight of organisms were observed during the study, therefore the NOEC is >= of the highest tested concentration of 60 mg/L (measured concentration 57.9 mg/L).
The 14d fish test is not considered as a chronic test because the sensitive life-stages (juveniles, eggs, larvae) are not exposed. It is, in effect, prolonged acute studies with fish mortality as the major endpoint examined. However, the results from this reliable study showed no effect to the growth of juvenile fish up to the highest tested concentration of 60 mg/L and an EC50 for the most sensitive species, the algae, was determined at 7.7 mg/L. Therefore, a chronic test with fish is not considered necessary to improve the PNECs neither for the classification process.
No data is available on TFA. The results from a valid acute test on fish showed no toxicity of TFANa up to the highest concentration tested (1200 mg/L) and an EC50 for the most sensitive species, the algae, was determined at 10.2 mg/L. Therefore, a chronic test with fish is not necessary to improve the PNECs neither for the classification process.
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