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EC number: 202-046-9 | CAS number: 91-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977-06 to 1978-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, sufficient information about test material, test organisms
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- publication
- Title:
- Acute inhalation toxicity of decalin in rodents
- Author:
- Kinkead ER, Wolfe RE, Bunger SK and Doyle RL
- Year:
- 1 977
- Bibliographic source:
- Acute Toxic Data 1, 215
Materials and methods
- Principles of method if other than guideline:
- Acute inhalation toxicity similar to OECD 403
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Decahydronaphthalene
- EC Number:
- 202-046-9
- EC Name:
- Decahydronaphthalene
- Cas Number:
- 91-17-8
- Molecular formula:
- C10H18
- IUPAC Name:
- decahydronaphthalene
- Details on test material:
- decahydronaphthalene (neat), no data on purity or isomer ratio
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
Species/ Strain: rats, Sprague-Dawley
Sex: male
Source: Harlan Industries Inc.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- 9 l glass chamber
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- hydrocarbon analyser
- Duration of exposure:
- 4 h
- Concentrations:
- 980, 820, 785, 625, 375 ppm
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - exposure to measured concentrations of the test substance to determine an 4 hour LC 50
- Duration of observation period following administration: 14 days - Statistics:
- Finney's probit analysis
Results and discussion
- Preliminary study:
- Exposure of 5 male rats each to saturated vapours for 4, 2 and 1-hour resulted in death of 5, 5 and 2 rats respectively. The rats were hyperactive early in the exposure but after approximately 40 minutes exhibited tonic convulsions, tremors and prostration. Rats that survived two hours or more of exposure were paralysed in the posterior half of the body and this paralysis persisted for several days. None of the paralysed rats survived the 14-day postexposure observation period.
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 710 ppm
- Based on:
- test mat.
- 95% CL:
- > 619 - < 816
- Exp. duration:
- 4 h
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4.08 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: calculated
- Mortality:
- All 5 animals died at 980 ppm, dose dependend decrease of mortality with non mortalities at 375 ppm
- Clinical signs:
- other: Animals displayed tremour and convulsions followed by prostration. Most survivours displayed hind quarter paralysis
- Gross pathology:
- Mild to severe congestion of the lungs with occasional areas of atelectasis was noted in animals that died. Reticulation of the liver and pale coloration of most organs was a common finding at all concentration levels.
Any other information on results incl. tables
Concentration ppm | Concentration mg/L | Mortality |
980 | 5.55 | 5/5 |
820 | 4.65 | 4/5 |
785 | 4.45 | 2/5 |
625 | 3.54 | 2/5 |
375 | 2.12 | 0/5 |
Applicant's summary and conclusion
- Conclusions:
- LC50 was determiend at 710 ppm ( with a 95% confidence intervall of 619-816 ppm). This corresponds to 4.08 mg/L air.
- Executive summary:
Male Sprague-Dawley rate (5 per group) a were exposed for 4 hours to varying concentrations of Decalin vapor (375 -980 ppm). Animals were exposed in a 9-liter glas chamber and observed for 14-days post exposure. Chamber concentrations were analyzed using a hydrocarbon analyzer. LC50 was calculated using Finney's probit analysis method. Reticulation of the liver and pale coloration of most organs was a common finding at all concentration levels.
Animals displayed tremors and convulsions followed by prostration. Most survivors displayed hind quarter paralysis. Gross pathologic examination of animals that died showed mild to severe congestion of the lungs with occasional areas of atelectasis.
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