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EC number: 288-003-5 | CAS number: 85631-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
To assess the irritancy potential of the mixed mixed Perfluoralkylethylacrylate to the skin an acute dermal irritation/corrosion toxicity study was performed in the New Zealand White rabbit according to OECD 404. Based on the results of this study the test substance is regarded as not irritant to the skin.
To assess the irritancy potential of the mixed mixed Perfluoralkylethylacrylate to the eye an acute eye irritation toxicity study was performed in the New Zealand White rabbit according to OECD 405. Based on the results of this study the test substance is regarded as not irritant to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin:
A single 4-hour, semi-occluded application of the test material to the intact skin of three rabbits did not produce any erythema or any oedema at all reading time points (i.e. 30 to 60 minutes, 24, 48 and 72 hours). In a second study the skin of 6 rabbits was occlusive exposed to the test item for 24 hours. In this test the test item produced slight erythema (score 1) with no edema in two rabbits and no dermal erythema or edema in four rabbits by 24 and 48 hours following application. By 72 hours, no dermal irritation was observed in the treated rabbits. Comparable results for dermal irritation were obtained with the read across substance in an OECD 404 study where the overall irritation score was determined to be 0.11.
Eye:
A single application of the test substance to the eye of three rabbits produced a slight conjunctivae reddening in all three animals at the 1-hour observation after instillation. At the 1 -hour observation a white to yellowish discharge were observed in one eye. The conjunctivae reddening persists as slight up to the 24-hour reading in two animals and was full reversible at the 48 -hour reading. No changes were observed at the corneal opacity, the iris, and chemosis of the conjunctivae at any time points (i.e. 30- 60 minutes, 24, 48 and 72 hours).
In an acute irritation study according to OECD 405 performed with the read across substance the individual mean scores for corneal opacity, conjunctival chemosis and changes of the iris were 0.00 for all three animals. The individual mean scores for the concunctivae reddening were 0.00, 0.33 and 0.00. The overall irritation score was determined to be 0.08.
In conclusion it is demonstrated that the registration substance as well as the read across substance have a similar low potential for skin and eye irritation.
Justification for classification or non-classification
According to the Regulation (EC) No 1272/2008 of the European Parliament and of the Council, 16 December 2008 (CLP or GHS (Global Harmonized System for classification, labeling and packaging) Annex 1, the test substance has not to be classified as skin or eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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