Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-482-4 | CAS number: 17465-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclooctapentylose
- EC Number:
- 241-482-4
- EC Name:
- Cyclooctapentylose
- Cas Number:
- 17465-86-0
- Molecular formula:
- C48H80O40
- IUPAC Name:
- cyclooctapentylose
- Details on test material:
- - Designation: .gamma.-cyclodextrin
- Date of receipt: October 11, 1990
- general appearance: white powder
- Batch no.: 888
- CAS. Reg. no.: 17465-86-0
- Storage conditions: ambient (circa 20°C)
Prior to the start of the study, the weight of 0.1 ml of the test substance was measured to be circa 0.063 gram.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Species: conventionally bred New Zealand White albino rabbits
Supplier: ENKI-Konijnenfarm, Someren, the Netherlands
Sex and age: males, young adult
Date of arrival: October 23, 1990
Body weight range at start of study: 2992-3129 g
Identification: earmarking: 5451-5453
Acclimatization period: 27 days
Caging: individually in suspended galvanized cages, fitted with wire-mesh floor and front
Lighting: 12 hours light/12 hours dark cycle
Temperature: 16-19 °C
Humidity: 62.5% - 80% (but higher for short periods of time after wet cleaning of the animal room)
Ventilation: ca. 10 air changes/hour
Diet: standard laboratory rabbit diet and tap water, ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eye served as a control
- Amount / concentration applied:
- An amount of 0.1 ml (0.063 g) of the test substance was instilled in the conjunctival cul-de-sac of the right eye of the rabbit.
- Duration of treatment / exposure:
- according to guideline
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- The study was started with one rabbit. After the acclimatization period both eyes of the rabbit selected were examined just before testing. Only rabbits without observable eye defects were to be used. The selected rabbit was treated as follows:
An amount of 0.1 ml (0.063 g) of the test substance was instilled in the conjunctival cul-de-sac of the right eye of the rabbit. After administration, the upper and lower eye lid were carefully closed and subsequently held together for at least one second before releasing, to prevent loss of material. The left eye remaining untreated, served as a control.
At one hour after treatment, only a slight eye effect was observed in this rabbit. Therefore, it was decided to complete the study with another two rabbits.
Ocular reactions of the test eye were judged at circa one hour, 24, 48, and 72 hours after treatment using the scoring scale.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- other: ocular discharge
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- At 1 hour after treatment, the eye effects observed in the three rabbits consisted of very slight redness with or without very swelling of the conjunctivae.
At 24 hours after treatment, the eye effects observed in the three rabbits consisted of very slight redness of the conjunctivae only.
At 48 hours after treatment, all eye effects had cleared completely.
At 72 hours after treatment again, no signs of eye irritation were observed in any of the three rabbits. - Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- On the basis of the results obtained it is concluded that, under the conditions of this study and according to the EEC-standards (mentioned in EEC-Directive 83/467/EEC and published in the Official Journal of the European Communities, L 257, Volume 26, 16 September 1983), .gamma.-cyclodextrin is not irritating or corrosive to eyes.
- Executive summary:
A sample of .gamma.-cyclodextrin was examined for acute eye irritating/corrosive properties in an experiment with three albino rabbits
The test substance caused slight redness with or without slight swelling of the conjunctivae. At 48 hours after treatment, all eye effects had cleared completely.
On the basis of the results obtained it was concluded that, under the conditions of this study and according to the EU standards, gamma.-cyclodextrin is not irritating or corrosive to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.