Registration Dossier
Registration Dossier
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EC number: 500-295-0 | CAS number: 106233-09-4 1 - 2.5 moles ethoxylated
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (3h) = 140 mg/L for activated sludge, read across
EC50 (16.9h) > 10 g for Pseudomonas putida, read across
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to aquatic microorganisms of alcohols, C16-18, ethoxylated, phosphates (CAS 106233-09-4) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 read across to the structurally similar alcohol ethoxylates (1-Dodecanol, ethoxylated, 4 EO, CAS No. 9002-92-0 and alkyl (C12-14) polyethyleneglycolether 6 EO, CAS 68439-50-9) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.
In a respiration test with 1-Dodecanol, ethoxylated, 4 EO (CAS 9002-92-0) using domestic activated sludge according to EG-guideline 88/302/EG and GLP (Diefenbach, 1997), an EC50 (3h) of 140 mg/L was determined. This finding is supported by a test with alkyl (C12 -14) polyethyleneglycolether 6 EO, CAS 68439 -50 -9) and Pseudomonas putida according to DIN 38412, part 8 and GLP (Diefenbach, 1996) revealing an EC50 (16.9 hours) > 10 g/L.
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