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EC number: 938-679-9 | CAS number: 308062-29-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 26/07/2010 - 11/08/2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 313.2 g/L
- Temp.:
- 30 °C
- pH:
- 4.95
- Conclusions:
- The water solubility was determined to be 313.2 g/L in this test, which was performed using freeze-dried C12-18 AO. Although the test samples gelled on standing, the result obtained is in line with the concentrations of C12-18 AO produced commercially.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well reported study
- Principles of method if other than guideline:
- A saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test susbtance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method (Disulfine Blue Active Substances, Ref. Q.W. Osburn, Analytical method for Cationic Fabric Softener in Water and Wastes, JAOCS vol 59, No 10 (October 1982) p 453-457.
- GLP compliance:
- no
- Water solubility:
- 409.5 g/L
- Remarks on result:
- other: No information on temperature or pH.
- Executive summary:
The water solubility of C12 -14 AO was determined to be 409.5 g/L.
Referenceopen allclose all
All flasks were gel-like and subsequently unable to determine water solubility on the samples in their present form, hence the addition of 50ml of HPLC water on 02/08/10 in order to obtain a water solubility value, continuation of shaking at 30ºC.
The mean concentrations of flasks 1, 2 and 3 were used to calculate the final water solubility result. The peak amount of Aromox BW-500 in solution was apparent after 48 hours shaking at 30ºC where 496.5 g/L was detected. Samples were diluted for
analysis as soon as they were removed from the shaker at 30ºC, if left for a short amount of time (approximately 1 - 2 minutes) the samples became a white solid. The samples could not be equilibrated at room temperature prior to analysis.
Description of key information
The water solubility is in the range of 313.2 - 409.5 g/L
Key value for chemical safety assessment
- Water solubility:
- 313.2 g/L
- at the temperature of:
- 30 °C
Additional information
No studies are available for C14-16 AO, however studies are available for two other members of the category – C12-14 AO and C12-18 AO. As these substances cover the chain length range of C14-16 AO it is considered appropriate to read across the values of water solubility obtained in the available studies to C14-16 AO.
In the study on C12 -14 AO [Lammens M & Rottiers A (2002)] a saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test substance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method. The water solubility of the substance was 409.5 g/L. No information is given in the report on stability of the lyophilised substance, but the result is in line with actual concentrations of amine oxide achieved during routine manufacturing and is considered to be reliable.
In the study on C12 -18 AO the water solubility was measured using EC Test Method A6. A water solubility of 313.2 g/L was obtained, but the samples gelled on standing and could not be equilibrated at room temperature prior to analysis. The value is considered to be valid, as C12 -18 AO is produced commercially as a 30 % w/v solution in water.
The solubility of C14-16 amine oxide is therefore considered to be in the range of 313.2 - 409.5 g/L.
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