Registration Dossier
Registration Dossier
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EC number: 269-927-8 | CAS number: 68391-08-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Both Key studies shows that there is no toxic effects up to the water solubility.
Key value for chemical safety assessment
Additional information
The study (SSO84111) was conducted under static conditions over a duration of 72 hours with an initial cell density of 104cells/mL and a saturated solution as limit concentration, containing 0.20 mg/L. For the preparation of the saturated solution a suspension with a nominal loading of 100 mg/L was shaken for 96 hours and centrifuged. The clear supernatant was used for the test.
The test vessels were coated with the test item for 14 days before the test started. Three replicates were tested for the limit concentration and six replicates for the control. The test item was clearly dissolved throughout the test. Microscopic evaluation of the cells at study start and end of the incubation period revealed no morphological abnormalities. Water quality parameters of pH-value, measured at 0 and 72 hours, and room temperature, measured continuously, were deemed to be within acceptable limits.
The initial measured concentration of the saturated solution was 0.20 mg/L. At the end of the test the concentration of the test item was below the detection limit of 0.009 mg/L. Sorption to the glass walls of the test vessels was unlikely as the walls were already pre-coated for 14 days prior to study start.
The 72-h EbC50 (inhibition of biomass growth) > 0.20 mg/L.
The 72-h ErC50 (rate related inhibition) > 0.20 mg/L.
The 72-h NOEC for both endpoints = 0.20 mg/L.
The 72-h LOEC for both endpoints was > 0.20 mg/L.
The study (SSO84112) was conducted under static conditions over a duration of 72 hours with an initial cell density of 104cells/mL and a water accomodated fraction as limit concentration, containing 0.47 mg/L. For the preparation of the water accomodated fraction a suspension with a nominal loading of 100 mg/L was shaken for 96 hours.
The test vessels were coated with the test item for 14 days before the test started. Three replicates were tested for the limit concentration and six replicates for the control. The test item was clearly dissolved throughout the test. Microscopic evaluation of the cells at study start and end of the incubation period revealed no morphological abnormalities. Water quality parameters of pH-value, measured at 0 and 72 hours, and room temperature, measured continuously, were deemed to be within acceptable limits.
The initial measured concentration of the saturated solution was 0.47 mg/L. At the end of the test the concentration of the test item was below the detection limit of 0.009 mg/L. Sorption to the glass walls of the test vessels was unlikely as the walls were already pre-coated for 14 days prior to study start.
The 72-h EbC50 (inhibition of biomass growth) > 0.47 mg/L.
The 72-h ErC50 (rate related inhibition) > 0.47 mg/L.
The 72-h LOEC for both endpoints was > 0.47 mg/L.
The 72-h NOEC for both endpoints = 0.47 mg/L.
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