Registration Dossier
Registration Dossier
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EC number: 414-420-0 | CAS number: - SPE 93279
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The only sources of data are a publication of 2004 (Willing A et al.) entitled "ecotoxicology and toxicology of Alkylpolyglucosides" and physico-chemical data performed on the test substance.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
According to Willing A et al., 2004, some toxicokinetics data on Alkylpolyglucosides (APG) can be noted: APGs are predicted to be bioavailable via the oral route. APGs undergo stepwise hydrolysis into glucose and fatty alcohol, which is further oxidized to the corresponding fatty acid are incorporated in the citrus cycle and partly in normal fat metabolism, respectively. Excretion is assumed to occur mainly via renal elimination. Tissue accumulation can be excluded.
Then, the absorption 's step can be estimated from the physico-chemical/toxicity data available on the substance:
- absorption by inhalation route:
The substance has a low vapor pressure (< 0.5 KPa) and so a low volatility triggering a weak exposition by the inhalation route. The moderate Log Kow value between -1 and 4 (1.1) is favourable for absorption directly across the respiratory tract epithelium by passive diffusion. The very high value of water solubility (790 g/l) could make that the vapours of the very hydrophilic substance may be retained within the mucus and transported out of the respiratory tract.
- absorption by dermal route:
The moderate Log Kow (1.1), molecular weight (292 -454 Da) values and the low vapor pressure are in favour of a dermal absorption. The very high water solubility value of the substance is in favour of a dermal uptake but the substance could be too hydrophylic to cross the lipid rich environment of the stratum corneum. The surface tension value (< 10 mN/m) shows that the substance will not enhance the potential dermal uptake. According to the toxicity data, the substance did not present an irritation nor a sensitizing potential for skin. These toxicity data do not permit to conclude on the dermal penetration.
- absorption by oral route:
The moderate Log Kow (1.1) and molecular weight (292 -454 Da) values are in favour of an oral absorption.
Water soluble substances will readily dissolve into the gastrointestinal fluids. Absorption of very hydrophilic substances by passive diffusion may be limited by the rate at which the substance partitions out the gastrointestinal fluid. An oral acute test shows a LD50 > 2000 mg/kg with 2 dead animals at 5000 mg/kg, so the oral absorption occured.
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