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Diss Factsheets
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EC number: 297-083-0 | CAS number: 93334-10-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 17 Aug-20 Aug 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report not available and documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- To assess the skin irritation potential of the test substance, it was applied to the shaved intact or abraded skin of animals (species not reported). The treated skin areas were observed for erythema and edema 24 and 72 hours after administration of the test substance. Only the intact skin was taken into account for assessment of the skin irritation potential of the test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sorbitan oleate
- EC Number:
- 215-665-4
- EC Name:
- Sorbitan oleate
- Cas Number:
- 1338-43-8
- Molecular formula:
- C24H44O6
- IUPAC Name:
- 1,4-anhydro-6-O-oleoyl-D-glucitol
- Details on test material:
- - Name of test material (as cited in study report): [trade name]
- Physical state: clear, yellow liquid
- Analytial purity: 100%
- Lot/batch No.: 9072C
Constituent 1
Test animals
- Species:
- other: no data
- Strain:
- other: not further specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated skin served as the control
- Observation period:
- 72 hours
- Number of animals:
- 3 males
- Details on study design:
- To assess the skin irritation potential of the test substance, it was applied to the shaved intact or abraded skin of animals (species not reported). The treated skin areas were observed for erythema and edema 24 and 72 hours after administration of the test substance. Only the intact skin was taken into account for assessment of the skin irritation potential of the test substance.
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean over 24 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean over 24 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean over 24 and 72 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- other: mean over 24 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritant / corrosive response data:
- Well-defined erythema was observed on the treated intact skin areas in 2/3 animals 24 hours after exposure ended. One of the treated skin areas exhibited a greater degree of erythema at the 72-hour reading time point, while the effect was completely reversed in the other animal. No erythema was observed in 1/3 animals at the 24- as well as the 72-hour reading time point. No edema was noted at any reading time point.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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