Registration Dossier
Registration Dossier
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EC number: 200-860-9 | CAS number: 75-31-0
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- other: Safety Data Sheet
Data source
Reference
- Reference Type:
- publication
- Title:
- Sikkerhedsdatablad Isopropylamin, Oxea
- Author:
- Oxea
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Limit test:
- yes
Test material
- Reference substance name:
- Isopropylamine
- EC Number:
- 200-860-9
- EC Name:
- Isopropylamine
- Cas Number:
- 75-31-0
- Molecular formula:
- C3H9N
- IUPAC Name:
- propan-2-amine
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEC
- Effect level:
- 500 mg/m³ air
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEC
- Effect level:
- 1 000 mg/m³ air
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No effects on maternal toxicity or teratogenicity was found. Therefore the respective NOAEC is 500 and 1000 mg/m3.
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