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EC number: 269-323-4 | CAS number: 68223-93-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetic studies are not available. The log Pow of 0.3 is suggestive of no accumulation potential of DADTDG. Furthermore, on the basis of the molecular structure excretion into urine as glucuronide or sulphate is assumed to be a preferred route of elimination. Elimination is assumed to be rapid. Therefore, no potential for bioaccumulation is to be expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 5
- Absorption rate - inhalation (%):
- 45
Additional information
Assessment of oral toxicokinetics based on the physicochemical properties of DADTDG:
Molecular weight 216
Water solubility 629 g/L
Partition coefficient log Kow = 0.3
The following remarks on the toxicokinetics of DADTDG are based on the available studies. Experimental toxicokinetic studies were only available for the main metabolite, the thioglycolic anion.
ABSORPTION
The physicochemical characteristics of DADTDG (log Pow 0.3) and the molecular mass are in a range suggestive of absorption from the lungs and the gastro-intestinal tract subsequent to oral ingestion, respectively. This assumption of an oral absorption is supported by the Danish EPA QSAR database (% G.I. abs. for 1 mg dose) predicting an oral absorption of 50% following an administered dose of 1 mg.
The EpiSuite DermWin v2.02 program predicts a low dermal absorption of 0.0084 mg/cm²/event, but absorption via the skin could be pH-dependent.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. This assumption is confirmed by the changes shown in the repeated dose toxicity studies conducted with the main metabolite of DADTDG, the thioglycolate anion following oral application. Cleavage of the disulfide bond leads to two molecules of the main metabolite, the thioglycolate anion and the toxicity and metabolism of the anion is very well investigated in many single- and repeat-dose toxicity studies. These studies suggest that after cleavage of DADTDG to thioglycolate anions the anions will preferably be either directly conjugated in a phase-II reaction or will excrete directly via the urine. DADTDG itself is found to enter the urine shortly after systemic administration of the thioglycolate anion described in a review from 2009 (Burnett et al., 2009).
ELIMINATION
The n-Octanol/water partition coefficient (log Pow of 0.3) is not suggestive of accumulation of unchanged DADTDG in fatty tissues subsequent to absorption from gastrointestinaltract or from lungs. Furthermore, studies with the main metabolite suggest full metabolism of the thioglycolate anion to unconjugated DADTDG and suphate and subsequent excretion into urine. Elimination is shown to be rapid. Therefore, no potential for bioaccumulation is to be expected
Assessment of oral toxicokinetics based on the physicochemical properties of DADTDG:
Molecular weight 216
Water solubility 629 g/L
Partition coefficient log Kow = 0.3
The following remarks on the toxicokinetics of DADTDG are based on the available studies. Experimental toxicokinetic studies were not available.
ABSORPTION
The physicochemical characteristics of DADTDG (log Pow 0.3) and the molecular mass are in a range suggestive of absorption from the lungs and the gastro-intestinal tract subsequent to oral ingestion, respectively. This assumption of an oral absorption is supported by the Danish EPA QSAR database (% G.I. abs. for 1 mg dose) predicting an oral absorption of 50% following an administered dose of 1 mg.
The EpiSuite DermWin v2.02 program predicts a low dermal absorption of 0.0084 mg/cm²/event, but absorption via the skin could be pH-dependent.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. This assumption is confirmed by the changes shown in the repeated dose toxicity studies conducted with the main metabolite of DADTDG the thioglycolate anion following oral application. Cleavage of the disulfide bond leads to two molecules of the main metabolite, the thioglycolate anion and the toxicity and metabolism of the anion is very well investigated in many single- and repeat-dose toxicity studies. These studies suggest that after cleavage of DADTDG to thioglycolate anions the anions will preferably be either directly conjugated in a phase-II reaction or will excrete directly via the urine. DADTDG itself is found to enter the urine shortly after systemic administration of the thioglycolate anion described in a review from Burnett et al., 2009.
ELIMINATION
The n-Octanol/water partition coefficient (log Pow of 0.3) is not suggestive of accumulation of unchanged DADTDG in fatty tissues subsequent to absorption from gastrointestinaltract or from lungs. Furthermore, studies with the main metabolite suggest full metabolism of the thioglycolate anion to unconjugated DADTDG and suphate and subsequent excretion into urine. Elimination is shown to be rapid. Therefore, no potential for bioaccumulation is to be expected
Assessment of oral toxicokinetics based on the physicochemical properties of DADTDG:
Molecular weight 216
Water solubility 629 g/L
Partition coefficient log Kow = 0.3
The following remarks on the toxicokinetics of DADTDG are based on the available studies. Experimental toxicokinetic studies were not available.
ABSORPTION
The physicochemical characteristics of DADTDG (log Pow 0.3) and the molecular mass are in a range suggestive of absorption from the lungs and the gastro-intestinal tract subsequent to oral ingestion, respectively. This assumption of an oral absorption is supported by the Danish EPA QSAR database (% G.I. abs. for 1 mg dose) predicting an oral absorption of 50% following an administered dose of 1 mg.
The EpiSuite DermWin v2.02 program predicts a low dermal absorption of 0.0084 mg/cm²/event, but absorption via the skin could be pH-dependent.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. This assumption is confirmed by the changes shown in the repeated dose toxicity studies conducted with the main metabolite of DADTDG the thioglycolate anion following oral application. Cleavage of the disulfide bond leads to two molecules of the main metabolite, the thioglycolate anion and the toxicity and metabolism of the anion is very well investigated in many single- and repeat-dose toxicity studies. These studies suggest that after cleavage of DADTDG to thioglycolate anions the anions will preferably be either directly conjugated in a phase-II reaction or will excrete directly via the urine. DADTDG itself is found to enter the urine shortly after systemic administration of the thioglycolate anion described in a Cosmetic Ingredient Review from 2009 (Burnett et al.).
ELIMINATION
The n-Octanol/water partition coefficient (log Pow of 0.3) is not suggestive of accumulation of unchanged DADTDG in fatty tissues subsequent to absorption from gastrointestinaltract or from lungs. Furthermore, studies with the main metabolite suggest full metabolism of the thioglycolate anion to unconjugated DADTDG and suphate and subsequent excretion into urine. Elimination is shown to be rapid. Therefore, no potential for bioaccumulation is to be expected (Burnett et al., 2009).
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