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EC number: 226-002-3 | CAS number: 5205-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29.05.2017 - 29.06.2017
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- adopted 17th July 1992.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Non-adapted activated sludge from the aeration tank of the ARA Werdhölzli (CH-8048 Zürich), a municipal biological waste water treatment plant. 30 mg/l dry matter in the final mixture.
- Concentration of sludge: 30 mg/l dry matter in the final mixture.
However, the sludge was pre-conditioned for 7 days (aerated but not fed) to reduce the amount of O2 consumed by the blank controls. For this pre-conditioning phase, the sludge was washed twice with tap water and once with test medium. After centrifugation, the sludge was suspended in test medium as described in Table 1, at about 2 g/l dry matter. Before the test, this suspension was diluted down to 60 mg/l dry matter, i.e. twice the final concentration, since this suspension was diluted 1:1 (v:v) afterwards (see below). - Duration of test (contact time):
- 28 d
- Initial conc.:
- 34 mg/L
- Based on:
- test mat.
- Initial conc.:
- 99 mg/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: containing inoculum, test medium and test item (two replicates)
- Additional substrate: None, N-(3-Dimethylaminopropyl)-methacrylamide and/or reference item as sole organic carbon sources
- Solubilising agent: no
- Test temperature: 22 ± 2°C, controlled at ± 1°C, in a thermostat cabinet in the dark
- pH: 7.4 (±0.2) adjusted with NaOH or HCl
Test concentrations:
- Test suspension, T: 34.0 mg/l test item (99.0 mg ThOD/l)
- Procedure control, R: 60.0 mg/l reference item (99.9 mg ThOD/l)
- Toxicity control, X: 34.0 mg/l test item and 60.0 mg/l reference item (total 199 mg oxygen demand /l)
- Abiotic sterile control, C: 34.0 mg/l test item (99.0 mg ThOD/l)
TEST SYSTEM
- Culturing apparatus: 510 ml glass bottles (tightly closed with manometric BOD measuring devices) containing a total volume of test solution of 200 ml. The bottles are equipped with stirring rods and butyl rubber quivers which contain 2 pellets of sodium hydroxide each to absorb the produced CO2 from the head space.
The test vessels were stirred by an inductive stirring system for a maximum test period of 28 days. During the test the O2 uptake was continuously measured with a manometric BOD measuring device. Temperature was recorded with a data logger.
At the end of the test, the pH was measured in all flasks except the abiotic sterile control (C), and the DOC content was determined in flasks T, B and R
- Number of culture flasks/concentration: 2 - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- n/a
- Test performance:
- n/a
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 87
- Sampling time:
- 28 d
- Remarks on result:
- other: readily biodegradable, 10-day window achieved
- Details on results:
- The biodegradability of N-(3-Dimethylaminopropyl)-methacrylamide based on O2 consumption was calculated to be 87% after 28 days as compared to the theoretical oxygen demand (ThOD).
While the lag-phase was different in each test unit (5 and 11 days for units 1 and 2 respectively), the kinetics of the biodegradation was highly comparable, yielding very similar values of biodegradation at the end of the respective 10-d windows: 82% and 84% days for units 1 and 2 respectively.
The procedure control with sodium benzoate reached 85% biodegradation after 14 days, thus confirming suitability of inoculum and test conditions.
The total elimination calculated based on dissolved organic carbon (DOC) measurements reached 99% for N-(3-Dimethylaminopropyl)-methacrylamide and for sodium benzoate. This data is in line with the degradation calculated based on O2 consumption.
N-(3-Dimethylaminopropyl)-methacrylamide (CAS no. 5205-93-6) reached the pass level of 60% for ready biodegradability in the Manometric Respirometry Test within the 10-d window and, therefore, can be termed as readily biodegradable.
All validity criteria were fulfilled. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The ready biodegradation of DMAPMA investigated in a Manometric Respirometry test over a period of 28 days and using domestic sewage as inoculum. Inoculum blank and procedural/functional control with the reference substance benzoic acid, sodium salt were performed.
While the lag-phase was different in each test unit (5 and 11 days for units 1 and 2 respectively), the kinetics of the biodegradation was highly comparable, yielding very similar values of biodegradation at the end of the respective 10-d windows: 82% and 84% days for units 1 and 2 respectively.
The biodegradability of N-(3-Dimethylaminopropyl)-methacrylamide based on O2 consumption was calculated to be 87% after 28 days as compared to the theoretical oxygen demand (ThOD).
The test item proved to be readily biodegradable and fulfilling the 10-d window criterion. - Executive summary:
The ready biodegradation of DMAPMA was investigated in a study conducted according to OECD Guideline 301 F (Manometric Respirometry Test), adopted 17th July 1992, and EU Method C.4 -C, 31 July 1992, over a period of 28 days using sewage sludge sampled from the aeration tank of a predominantly domestic sewage treatment plant as inoculum. The biodegradation rate was determined by measurement of O2 consumption. Inoculum blank and procedural/functional control with the reference substance benzoic acid, sodium salt were performed.
The test item proved to be readily biodegradable and fulfilling the 10-d window criterion.
While the lag-phase was different in each test unit (5 and 11 days for units 1 and 2 respectively), the kinetics of the biodegradation was highly comparable, yielding very similar values of biodegradation at the end of the respective 10-d windows: 82% and 84% days for units 1 and 2 respectively.
The biodegradability of N-(3-Dimethylaminopropyl)-methacrylamide based on O2consumption was calculated to be 87% after 28 days as compared to the theoretical oxygen demand (ThOD).
This study is regarded as reliable without restriction and satisfies the guideline requirements for ready biodegradation. DMAPMA proved to be readily biodegradable and fulfilling the 10-d window criterion.
Reference
Description of key information
N-[3-Dimethylamino)propyl]methacrylamide is readily biodegradable in a Manometric Respirometry test according OECD 301 F. 87 % degradation within 28 days, fulfilling 10 day window.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
N-[3-Dimethylamino)propyl]methacrylamide is readily biodegradable in a Manometric Respirometry test according OECD 301 F. 87 % degradation within 28 days, fulfilling 10 day window.
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