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EC number: 250-157-6 | CAS number: 30374-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Sept 1998 - 20 Oct 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Department of health of the government of the United Kingdom
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Isooctyl 3-mercaptopropionate
- EC Number:
- 250-157-6
- EC Name:
- Isooctyl 3-mercaptopropionate
- Cas Number:
- 30374-01-7
- Molecular formula:
- C11H22O2S
- IUPAC Name:
- 2-methylheptyl 3-sulfanylpropanoate
- Details on test material:
- - Name of test material (as cited in study report): Iso-octyl 3-mercaptopropionate
- Analytical purity: 99.6% w/w
- Purity test date: 1996-10-01
- Lot/batch No.: B98E2688
- Physical state: colourless liquid
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Margate, Kent
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: males: 201 - 232 g; females: 200 - 218 g
- Fasting period before study: overnight fast
- Housing: Animals were housed in groups of up to five by sex in solid-floor polypropylene cages furnished with woodflakes.
- Diet (ad libitum): free access to food (Rat and Mouse Expanded Diet No. 1, Special Diets Services Limited, Witham, Essex, UK)
- Water (ad libitum): free access to mains drinking water
- Acclimation period: minimum acclimation period of five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 22
- Humidity (%): relative 43 - 70
- Air changes (per hr): approximately 15 x / hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 35.4, 50.0 or 70.7 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: Arachis oil was used because the test material did not dissolve in distilled water. - Doses:
- Males: 354, 500 and 707 mg/kg bw
Females: 354 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: ½, 1, 2, 4 hours after dosing and subsequently once daily for 14 days
- Frequency of observations and weighing: once daily, body weight was recorded on day 0 and on days 7 and 14 or at death
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Using the mortality data obtained, the acute oral median lethal dose (LD50) and 95 % confidence limits of the test material were calculated using a probit method of Finney D.J. ´Probit Analysis´1971, Cambridge University Press. The LD50 and 95 % confidence limits were calculated for males only.
Results and discussion
- Preliminary study:
- The male treated with 500 mg/kg bw was found dead four hours after dosing. Clinical signs of toxicity noted in the animal treated with 500 mg/kg bw were hunched posture, lethargy, decreased respiratory rate, labored respiration, ataxia, occasional body tremors, pilo-erection and ptosis. The female treated with 500 mg/kg bw recovered four days after dosing. Hunched posture was noted in animals treated with 50 mg/kg during the day of dosing and up to one day after dosing.
Based on this information, dose levels of 707, 500 and 354 mg/kg body weight were selected for the main study.
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 674 mg/kg bw
- 95% CL:
- > 454 - <= 1 000
- Mortality:
- Deaths were noted at dose levels of 707 (3 males found dead approximately 3 hours after dosing) and 500 mg/kg (1 male 2 hours after dosing) bw during the day of dosing (Table 1).
- Clinical signs:
- other: Common signs of systemic toxicity noted in all dose groups were hunched posture, lethargy, decreased respiratory rate and labored respiration. Ataxia was commonly noted in animals treated with 707 and 500 mg/kg bw. Common signs of systemic toxicity noted
- Gross pathology:
- Abnormalities noted at necropsy of animals that died during the study were hemorrhagic or abnormally red lungs, dark liver and dark kidneys. No abnormal findings were observed at necropsy of animals that were killed at the end of the study.
- Other findings:
- Female animals were considered not to be markedly more sensitive to the test material than male animals.
Any other information on results incl. tables
Table 1. Acute oral toxicity of IOMP |
||||
Dose [mg/kg bw] |
Toxicological results* |
Time of death |
Mortality (%) |
|
Males |
|
|||
354 |
0/5/5 |
– |
0 |
|
500 |
1/5/5 |
1 h |
20 |
|
707 |
3/5/5 |
4 h |
60 |
|
LD50= 674 mg/kg bw |
|
|||
Females |
|
|||
354 |
0/5/5 |
– |
0 |
|
* first number = number of dead animals
second number = number of animals with signs of toxicity
third number = number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 = 674 mg/kg bw
- Executive summary:
In a study according to OECD TG 401, male and female Sprague-Dawley rats (5/sex/dose) were administered a single dose of iOMP at dose levels of 354, 500 and 707 mg/kg bw (males) or 354 mg/kg bw (females). The animals were observed for 14 days.
Deaths were noted at dose levels of 707 (3 males found dead approximately 3 hours after dosing) and 500 mg/kg (1 male 2 hours after dosing) bw during the day of dosing.
Common signs of systemic toxicity noted in all dose groups were hunched posture, lethargy, decreased respiratory rate and labored respiration. Ataxia was commonly noted in animals treated with 707 and 500 mg/kg bw. Common signs of systemic toxicity noted in animals treated with 707 mg/kg bw were prostration, clonic and tonic convulsions. Occasional body tremors were commonly noted in females treated with 354 mg/kg bw with incidents of occasional body tremors noted in animals treated with 707 and 500 mg/kg bw. Incidents of vocalization and chromodacryorrhoea were noted in animals treated with 707 mg/kg bw with incidents of prostration, increased salivation and ptosis and an isolated incident of pilo-erection noted in animals treated with 500 mg/kg bw. Incidents of splayed gait were noted in animals treated with 500 and 354 mg/kg bw with incidents of ataxia noted in males treated with 354 mg/kg.
Surviving animals recovered four to eight days after dosing.
The LD50 (males) was 674 mg/kg bw.
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