Dodecyldimethylamine oxide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

A saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test susbtance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method (Disulfine Blue Active Substances, Ref. Q.W. Osburn, Analytical method for Cationic Fabric Softener in Water and Wastes, JAOCS vol 59, No 10 (October 1982) p 453-457.

GLP compliance:

no

Type of method:

flask method

Water solubility:

409.5 g/L

Remarks on result:

other: No information on temperature or pH.

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)

Description of key information

The water solubility is 409.5 g/L, based on read across to a study performed using C12-14 AO.

Key value for chemical safety assessment

Water solubility:

409.5 g/L

at the temperature of:

30 °C

Additional information

No study is available for C12 AO however a study is available for another member of the amine oxide category, C12-14 AO. In this study [Lammens M & Rottiers A (2002)] a saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test substance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method. The water solubility of the substance was 409.5 g/L. No information is given in the report on stability of the lyophilised substance, but the result is in line with actual concentrations of amine oxide achieved during routine manufacturing and is considered to be reliable. This result is read across to C12AO and is likely to represent a worse case as the pure C12 AO is expected to have an increased water solubility compared to the C12-14 AO.