Registration Dossier
Registration Dossier
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EC number: 231-912-9 | CAS number: 7778-74-7
Carcinogenicity
Administrative data
Description of key information
Two non-standard published studies are available, using oral administration.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- Two non-standard published studies are available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
A tumour promoting ability of potassium perchlorate is shown in the rat thyroid (following inititation with radioactive iodine isotope); however the substance itself is not shown to be carcinogenic. No classification for carcinogenicity is proposed based on the data available.
Additional information
Fernandez-Santos et al (2004) report the ability of potassium perchlorate administration at a high oral dose level (1% in drinking water) to promote thyroid tumours initiated by the administration of radioactive iodine isotope. This property is not suprising given the known proliferative effects of perchlorate on the thyroid, but the relevance to the risk assessment is not clear.
Justification for selection of carcinogenicity via oral route endpoint:
Study reports evidence of thyroid tumour promotion activity following initiation with radioactive iodine
Carcinogenicity: via oral route (target organ): glandular: thyroids
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