Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-274-1 | CAS number: 7474-78-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guidelineopen allclose all
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 3,4-diaminobenzenesulphonic acid
- EC Number:
- 231-274-1
- EC Name:
- 3,4-diaminobenzenesulphonic acid
- Cas Number:
- 7474-78-4
- Molecular formula:
- C6H8N2O3S
- IUPAC Name:
- 3,4-diaminobenzene-1-sulfonic acid
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -3.42
- Temp.:
- 22 °C
- pH:
- > 3 - < 4
Any other information on results incl. tables
The partition coefficient (1-octanol/water) of 3,4-diaminobenzenesulfonic acid was determined according to European Commission Council Regulation (EC) No 440/2008, Annex, Part A, A.8., Shake Flask Method. Three different mixtures of double distilled water, 1-octanol, a blank and the stock solution were prepared. The concentrations of the test item in none of these phases exceeded the maximum concentration of 0.01 mol/L. The test item concentration was determined by HPLC. For calibration the external standard method was applied. The found log POW value is outside the shake flask method range of log POW -2 to +4. Nonetheless the determined partition coefficents were in the range of +- 0.3 log units. The partition coefficient (1-octanol / water) of 3,4 -diaminobenzenesulfonic acid is
POW = 3.8222 x10-4 ± 3.8317 x10 -5
log POW =- 3.42 ± 0.04
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
