Reaction mass of [(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (1S,2R,4aS,6aR,6aR,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate and [(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate

Guidance on Safe Use

First-aid measures

* Description of first aid measures

- Eye contact: Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs.

- Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Get medical attention if symptoms occur.

- Skin contact:Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur.

- Ingestion: Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.

- Protection of first-aiders: No action shall be taken involving any personal risk or without suitable training.

* Most important symptoms and effects, both acute and delayed

Potential acute health effects

- Eye contact: Exposure to airborne concentrations above statutory or recommended exposure limits may cause irritation of the eyes.

- Inhalation: Exposure to airborne concentrations above statutory or recommended exposure limits may cause irritation of the nose, throat and lungs.

- Skin contact: No known significant effects or critical hazards.

- Ingestion: No known significant effects or critical hazards.

Over-exposure signs/symptoms

- Eye contact: Adverse symptoms may include the following: irritation, redness

- Inhalation: Adverse symptoms may include the following: respiratory tract irritation, coughing

- Skin contact: No specific data

- Ingestion: No specific data

* Indication of any immediate medical attention and special treatment needed

- Notes to physician: Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

- Specific treatments: No specific treatment

Fire-fighting measures

* Extinguishing media

- Suitable extinguishing media: Use dry chemical powder.

- Unsuitable extinguishing media: Do not use water jet.

* Special hazards arising from the substance or mixture

- Hazards from the substance or mixture: Fine dust clouds may form explosive mixtures with air.

- Hazardous thermal decomposition products: Decomposition products may include the following materials: carbon dioxide, carbon monoxide

* Advice for firefighters

- Special protective actions for fire-fighters: Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool.

- Special protective equipment for fire-fighters: Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Clothing for fire-fighters (including helmets, protective boots and gloves) conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.

Accidental release measures

* Personal precautions, protective equipment and emergency procedures

- For non-emergency personnel: No action shall be taken involving any personal risk or without suitable training.

Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Shut off all ignition sources.

No flares, smoking or flames in hazard area. Avoid breathing dust. Put on appropriate personal protective equipment.

- For emergency responders: If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".

* Environmental precautions:

Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).

* Methods and material for containment and cleaning up

- Small spill: Move containers from spill area. Use spark-proof tools and explosion-proof equipment. Vacuum or sweep up material and place in a designated, labelled waste container. Dispose of via a licensed waste disposal contractor.

- Large spill: Move containers from spill area. Use spark-proof tools and explosion-proof equipment. Approach the release from upwind. Prevent entry into sewers, water courses, basements or confined areas. Vacuum or sweep up material and place in a designated, labelled waste container. Avoid creating dusty conditions and prevent wind dispersal. Dispose of via a licensed waste disposal contractor.

* Reference to other sections:

See Section 1 for emergency contact information.

See Section 8 for information on appropriate personal protective equipment.

See Section 13 for additional waste treatment information.

Handling and storage

* Precautions for safe handling

- Protective measures: Put on appropriate personal protective equipment (see Section 8). Avoid breathing dust. Avoid the creation of dust when handling and avoid all possible sources of ignition (spark or flame). Prevent dust accumulation. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Electrical equipment and lighting should be protected to appropriate standards to prevent dust coming into contact with hot surfaces, sparks or other ignition sources. Take precautionary measures against electrostatic discharges. To avoid fire or explosion, dissipate static electricity during transfer by earthing and bonding containers and equipment before transferring material.

- Advice on general occupational hygiene: Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

- Typical static discharges precautions: Low ignition sensitivity

* Conditions for safe storage, including any incompatibilities:

Store in accordance with local regulations. Store in a segregated and approved area.

Store in original container protected from direct sunlight in a dry, cool and wellventilated area, away from incompatible materials (see Section 10) and food and drink. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination.

* Specific end use(s)

- Recommendations: Not available.

- Industrial sector specificsolutions: Not available.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

Not regulated.

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

Not regulated.

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

Not regulated.

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

Not regulated.

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

* Control parameters

Occupational exposure limits:

No exposure limit value known.

- Recommended monitoring procedures: If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to monitoring standards, such as the following: European Standard EN 689 (Workplace atmospheres - Guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy) European Standard EN 14042 (Workplace atmospheres - Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents) European Standard EN 482 (Workplace atmospheres - General requirements for the performance of procedures for the measurement of chemical agents) Reference to national guidance documents for methods for the determination of hazardous substances will also be required.

DNELs/DMELs: No DNELs/DMELs available.

PNECs: No PNECs available

* Exposure controls

- Appropriate engineering controls: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapour or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. The engineering controls also need to keep gas, vapour or dust concentrations below any lower explosive limits. Use explosion-proof ventilation equipment.

- Hygiene measures: Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

Individual protection measures

- Eye/face protection: Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields. If operating conditions cause high dust concentrations to be produced, use dust goggles.

- Hand protection: Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary.

- Body protection: Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

- Other skin protection: Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

- Respiratory protection: Use a properly fitted, particulate filter respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.

Environmental exposure controls: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Stability and reactivity

* Reactivity: No specific test data related to reactivity available for this product or its ingredients.

* Chemical stability: The product is stable.

* Possibility of hazardous reactions: Under normal conditions of storage and use, hazardous reactions will not occur

* Conditions to avoid: Avoid the creation of dust when handling and avoid all possible sources of ignition (spark or flame). Take precautionary measures against electrostatic discharges. To

avoid fire or explosion, dissipate static electricity during transfer by earthing and bonding containers and equipment before transferring material. Prevent dust accumulation.

* Incompatible materials: Reactive or incompatible with the following materials: oxidizing materials

* Hazardous decomposition products: Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

* Waste treatment methods

Product

- Methods of disposal: The generation of waste should be avoided or minimised wherever possible.

Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.

- Hazardous waste: Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 91/689/EEC.

Packaging

- Methods of disposal : The generation of waste should be avoided or minimised wherever possible. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible.

- Special precautions:This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers.