Registration Dossier
Registration Dossier
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EC number: 946-354-8 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.25 mg/m³
DNEL related information
- DNEL derivation method:
- other: OEL from SCOEL for CrIII
- Explanation for the modification of the dose descriptor starting point:
For CrIII a OEL was set by SCOEL at 0.5 mg/m3. This value was transfered to the value for the UVCB based on a CrIII content of 8%, leading to the value of 6.25 mg/m3.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25 mg/m³
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
For CrIII a short-tterm OEL was set by SCOEL at 2 mg/m3. This value was transfered to the value for the UVCB based on a CrIII content of 8%, leading to the value of 25 mg/m3.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/kg bw/day
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The EFSA Contam Panel has derived a TDI of 0.3 mg/kg bw/d. For worker an adjustment factor of two was used leading to 0.6 mg/kg bw/d. This value was transfered to the value for the UVCB based on a CrIII content of 8%, leading to the value of 7.5 mg/kg bw/d.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/kg bw/day
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.25 mg/m³
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
Same value as for worker was used, as route to route extrapolation from EFSA TDI leads to a higher value: 0.3 x70/20 = 1.05 mg/m3 CrIII => 13.125 mg/n3 UVCB
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.25 mg/m³
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.75 mg/kg bw/day
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The EFSA Contam Panel has derived a TDI of 0.3 mg/kg bw/d. This value was transfered to the value for the UVCB based on a CrIII content of 8%, leading to the value of 3.75 mg/kg bw/d.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.75 mg/kg bw/day
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.75 mg/kg bw/day
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The EFSA Contam Panel has derived a TDI of 0.3 mg/kg bw/d. This value was transfered to the value for the UVCB based on a CrIII content of 8%, leading to the value of 3.75 mg/kg bw/d.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.75 mg/kg bw/day
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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