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EC number: 946-354-8 | CAS number: -
10 guinea pigs were exposed to 5 injections of 0.2 ml each of an emulsion containing either 2 mg chromium chloride/ml in Freund’s complete adjuvant (FCA) into the footpad and nape of the neck. The animals were restimulated once a week by intradermal injections of 25 µg of chromium trichloride. Simultaneously, 0.02 ml of 0.5% chromium trichloride in 1% Triton X-100 was applied epicutaneously to the skin of the opposite flank. The boosting was continued weekly until a positive reaction was observed. Four to six weeks after the positive skin reaction had emerged, the animals were challenged epicutaneously with both haptens, and skin inflammation was evaluated 24 h later. Seven out of 10 guinea-pigs sensitized and boosted with chromium trichloride responded to an epicutaneous challenge with chromium trichloride.
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