Registration Dossier
Registration Dossier
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EC number: 940-543-9 | CAS number: 354-15-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Since the only available study report for this endpoint does not contain essential information for an appropriate evaluation of the results, the study it has been discarded. Specifically, the following information are missing:
- volume of injected solutions and identity of the solvent
- number of animals involved in the test
- number of positive responses
- presence of positive/ negative control groups
- type of coverage used at the challenge
- recovery
- statistic
Therefore, in order to assess the potential skin sensitisation properties of HCFC 122a, the read across approach with similar compounds has been taken into account. In scientific literature some experimental results on HCFCs exist. Since no skin sensitisation properties for chemicals with analogue structures of HCFC 122a are reported, it can be concluded that HCFC 122a does not pose concern for this property.
Migrated from Short description of key information:
Since the only available study report for this endpoint does not contain essential information for an appropriate evaluation of the results, the study it has been discarded and the read across approach with analogue susbtances has been applied in order to assess the skin sensitisation properties of HCFC 122a. Basing on experimental data on similar compounds deriving from scientific literature it can be concluded that HCFC 122a does not pose concern for skin sensitisation.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
