Registration Dossier
Registration Dossier
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EC number: 291-378-8 | CAS number: 90388-00-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro:
The substance Heptadecanol N was tested for its mutagenic potential based on the ability to induce point mutations in selected loci of several bacterial strains, i.e. Salmonella typhimurium and Escherichia coli ( TA 1535, TA 100, TA 1537, TA 98 and E. coli WP2 uvrA), in a reverse mutation assay according to OECD 471 guideline (BASF, 2007). The test substance was tested at doses ranging from 20 μg to 5 000 μg/plate in the standard plate test (SPT) and the preincubation test (PIT) both with and without metabolic activation (Aroclor-induced rat liver S9 mix). Precipitation of the test substance was found from 500 μg/plate onward with and without S9 mix. A weak bacteriotoxic effect was occasionally observed depending on the strain and test conditions from about 2 500 μg/plate onward. An increase in the number of his+ or trp+ revertants was not observed in the standard plate test or in the preincubation test either without S9 mix or after the addition of a metabolizing system. According to the results of the present study, the test substance Heptadecanol N is not mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay under the experimental conditions chosen here.
In vivo:
This information is not available
Short description of key information:
Ames-Test: negative (BASF, 2007)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No mutagenicity was observed in an Ames test according to OECD 471 guideline. Therefore, the test substance has not to be classified according to EU (67/548/EEC)- and CLP (1272/2008/EC) requirements for this endpoint.
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