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EC number: 279-506-0 | CAS number: 80584-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- EL
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Source: own rearing, original source Water Research Institute, Bratislava, Slovak Republic
- Age at study initiation (mean and range, SD): < 24 h
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 21.2 - 22.0 °C
- pH:
- 8.14 - 8.20
- Dissolved oxygen:
- 6.01 - 6.65 mg/L
- Nominal and measured concentrations:
- 3300 mg/L (nominal concentration, initial)
measured concentrations: From the results of UV/Vis spectrometric measurements is evident that the concentration of the substance has been satisfactorily maintained within required +-20% of the nominal concentration throughout the test. (Deviation of nominal : + 6.7%/ +16.1% l at beginning/ end of test) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 10 mL
- Type: closed
- Material: glass or other chemically inert material
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 2 mL/animal
- Holding water: dechlorinated tap water (Chlorine: < 10 µg/L, 151 mg/L (CaCO3))
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ISO 6341 test water which was aereated before use.
- Intervals of water quality measurement: oxygen and pH measured at beginning and end of test
OTHER TEST CONDITIONS
- Adjustment of pH: yes, 1 N NaOH to pH 8.2 to ensure solubility of the test substance
- Photoperiod: 16 h light / 8 h dark
EFFECT PARAMETERS MEASURED:
immobilisation recorded at 24 and 48 h
TEST CONCENTRATIONS
- 3300 mg/L
- Range finding study: yes - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3 300 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - 48 h-EC50: 0.68 mg/L (mean of 3 determinations)
- Validity criteria fulfilled:
- yes
- Executive summary:
The short term toxicity of TC to Daphnia magna was tested according to OECD guideline 202. 10% immobilisation was observed within 48 h at the only tested concentration of 3300 mg/L. Therefore, the 48h-EC50 was determined to be >3300 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, well documented, according to national australian guideline wich is comparable to more widespread used guidelines. acceptable for assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: New South Wales Gouvernment Environment Protection Authority: ASTM Designation E1192 (1988)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solutions, stirred in the dark; diluted to the appropriate concentrations immediately prior to the commencement of the test.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): no - Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Common name: Ceriodaphnia cf. dubia
- Source: laboratory
- Age at study initiation (mean and range, SD): < 24 h
- Method of breeding: cultures were maintained in 2-L glass beakers and transferred to fresh water three times weekly. Food was provided after water renewal (unicellular algae: Pseudokircheneriella subcapitata and Ankistrodesmus sp., each at 25000 cells/mL)
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 23±1 °C
- Nominal and measured concentrations:
- series of 5 test concentrations plus control
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers
- Material, size, headspace, fill volume: 250-mL glass beakers, fill volume: 200 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
- Biomass loading rate: 1 animal / 40 mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tapwater, filtered (1 µm), aged (1 month), adjusted to 500 µS/cm with seawater
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8 h light:dark cycle
- Light intensity: 1000 lux at surface
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- measurements:
- number of immobile cladocera counted at the end of test
- pH, dissolved oxygen, conductivity at test initiation before test animals were added and at test completion
TEST CONCENTRATIONS
- Spacing factor for test concentrations: no data
- Justification for using less concentrations than requested by guideline: not applicable
- Range finding study: performed
- Test concentrations: no data - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 609.88 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% confidence interval 565.2 mg/l - 658.3 mg/l
- Reported statistics and error estimates:
- The 48-h EC50 (immobilisation) values and the corresponding 95 % confidence intervals were based on nominal concentrations and were determined by the trimmed Spearman-Kaerber method (Hamilton et al., 1977).
- Validity criteria fulfilled:
- yes
Referenceopen allclose all
Immobilisation at 3300 mg/L: 0% after 24 h, 10% after 48 h
Description of key information
The compound consists of a triazine part and an amine part. Under environmental conditions it is present in its dissociated form. Therefore, separate assessments were conducted for the triazine and the amine part, respectively.
CAS 80584-91-4: There is a high probability that the compound is not acutely harmful to aquatic invertebrates.
CAS 102 -71 -6: There is a high probability that the compound is not acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
The compound consists of a triazine part and an amine part. Under environmental conditions it is present in its dissociated form. Therefore, separate assessments were conducted for the triazine and the amine part, respectively.
CAS 80584-91-4
The acute toxicity to invertebrates was assessed in a 48-h acute toxicity to Daphnia magna study in accordance to OECD guideline 202. The test was conducted as limit test under static conditions with a concentrations of 3300 mg/L. The 48-h EC50 was determined to be > 3300 mg/L. Additionally, supporting data on the acute toxicity to invertebrates according to OECD 202 within 24-h is available. The test was conducted under static conditions with measured concentrations of 10, 18, 32, 58, 100, 180 mg/L. The 24-h EC50 was determined to be > 180 mg/L.
CAS 102-71-6
The key study identified for the acute toxicity to aquatic invertebrates is a test performed by Warne et al. (1999) according to ASTM Designation E1192. Using Ceriodaphnia dubia as test species in a static procedure an EC50 of 609.88 mg/l after 48 hours of exposure was calculated related to the nominal concentrations. Hence, the chemical is considered to be acutely not harmful fo invertebrates. Other data which are available for 2,2’,2’’-nitrilotriethanol are disregarded and shout not be used for risk assessment purposes mainly due to the insufficient exposure duration.
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