Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 277-823-9 | CAS number: 74336-59-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
In ECHA's Guidance Document on information requirements and chemical safety assessment Chapter R.7c (R.7.10.3.4, p. 23ff) and Chapter R.11(R.11.1.3.2, p. 27f) it is laid out that several substance properties (e.g. logPow, molecular size of substance) can be combined in a weight of evidence approach to evaluate the substance's bioaccumulation potential.
The evaluation of physico-chemical substance properties resulted in a logPow of 2 for Pigment Orange 67 which indicates that the substance is expected to be rather hydrophobic with a low potential for bioaccumulation. Other supporting indicators are the molecular length (4.4 nm) and molecular diameter (4.6 nm) of Pigment Orange 67. Both values exceed their established threshold limits (threshold molecular length of 4.3 nm; threshold molecular diameter of 1.7 nm) which results either in the substance disturbing the entire interior structure of the lipid bilayer of cell membranes or in the failure of the molecule to cross cell membranes because it is simply too bulky to do so. Both factors result in a reduced BCF of the substance.
Therefore, it can be expected that Pigment Orange 67 has a low bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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