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EC number: 275-604-2 | CAS number: 71550-24-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Five rats/sex received 2.0, 3.1 and 5.0 mL/kg of the substance by oral gavage. Mortality was observed at 3.1 mL/kg (1 female) and at 5 mL/kg (1 male and 3 females). Bodyweight gain was decreased in males dosed at 5.0 mL/kg. Clinical signs included poor condition, piloerection and sedation in animals at 3.1 mL/kg and above. At necropsy erosion of the stomach mucosa and hardening of the fundus area was seen in decedents (Bayer 1985).
The LD50 of the substance tested is > 5.0 mL/kg bw (corrected for purity > 3.5 mL/kg).
This result is confirmed by another test where the LD50 was assessed to be 3800 mg/kg bw (Bayer 1983).
In view of these results that are indicative for low toxicity and the fact that the substance is corrosive the acute dermal study has been waived.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 October 1985 to 4 November 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- non GLP
- Qualifier:
- according to guideline
- Guideline:
- other: EEC 84/49
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Borchen
- Females (if applicable) nulliparous and non-pregnant: no data
- Age at study initiation: males 9 weeks; females 14 weeks
- Weight at study initiation: males 164-182 g; females 164-172 g
- Fasting period before study: 16 hours before and 4 hours after dosing
- Housing: 5/sex/cage in Macrolon Type III cages
- Diet: pelleted diet (Altromin R 1324, Altromin GmbH, Lage) ad libitum
- Water: tap water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 50 ± 10%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2.0, 3.1 and 5.0 mL/ kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Body weight: at test start and on day 7 and 14
- Frequency of clinical observations: several times on day 1 and twice daily thereafter
- Necropsy of survivors performed: yes - Statistics:
- NA
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mL/kg bw
- Based on:
- test mat.
- Mortality:
- males: 1 at 5.0 mL/kg
females: 1 at 3.1 mL/kg and 3 at 5.0 mL/kg - Clinical signs:
- poor condition, sedation and piloerection at 3.1 and 5.0 mL/kg
- Body weight:
- decreased in males at 5.0 mL/kg and in 1 male at 3.1 mL/kg
- Gross pathology:
- damage of the gastric mucosa and hardening of the fundus in decedents
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the substance tested the LD50 is > 5.0 mL/kg bw (recalculation based on purity 3.5-3.75 mL/kg)
- Executive summary:
Five rats/sex received 2.0, 3.1 and 5.0 mL/kg of the substance by oral gavage. Mortality was observed at 3.1 mL/kg (1 female) and at 5 mL/kg (1 male and 3 females). Bodyweight gain was decreased in males dosed at 5.0 mL/kg. Clinical signs included poor condition, piloerection and sedation in animals at 3.1 mL/kg and above. At necropsy erosion of the stomach mucosa and hardening of the fundus area was seen in decedents
The LD50 of the substance tested is > 5.0 mL/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 500 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- waiver based on corrosivity
Additional information
Justification for classification or non-classification
Based on the information available the substance does not need to be classified for acute toxicity according to Regulation (EC) No 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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