Registration Dossier
Registration Dossier
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EC number: 268-459-1 | CAS number: 68092-46-6
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- yes
- Remarks:
- source of test material not stated; information on test conditions not reported
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-toluic acid
- EC Number:
- 202-723-9
- EC Name:
- m-toluic acid
- Cas Number:
- 99-04-7
- Molecular formula:
- C8H8O2
- IUPAC Name:
- 3-methylbenzoic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: light yellow crystalline powder
- Melting point: 111.3 °C
- Boiling point: 263 °C
- Molecular weight: 136.15 g/mol
Constituent 1
- Radiolabelling:
- not specified
Study design
- Analytical monitoring:
- not specified
- Buffers:
- Buffer not specified in report.
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks: glass test tube with stopper
- Sterilisation method: not reported
- Lighting: not reported
TEST MEDIUM
- No information on test medium reported
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Number of replicates:
- 2
- Positive controls:
- not specified
- Negative controls:
- not specified
Results and discussion
- Preliminary study:
- As a result of the preliminary test, it was judged that the test substance was not hydrolyzable at pH 4, 7 and 9.
- Transformation products:
- not specified
- Details on results:
- As a result of the preliminary test, it was judged that the test substance was not hydrolyzable at pH 4, 7 and 9.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Only limited information on test conditions and results is provided. Although the study was performed according to OECD guideline 111, it is not possible to confirm full guideline compliance. It remains unclear from which analytical results it was concluded that m-toluic acid is not hydrolyzable and that further testing is not required. Thus, this study is considered supporting data.
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