Registration Dossier
Registration Dossier
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EC number: 258-416-5 | CAS number: 53179-11-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Loperamide
- EC Number:
- 258-416-5
- EC Name:
- Loperamide
- Cas Number:
- 53179-11-6
- Molecular formula:
- C29H33ClN2O2
- IUPAC Name:
- 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
- Details on test material:
- Name Loperamide base (CAS 53179-11-6)
Batch no. 02742200215
Purity 99.5 %
Expiry date 20. Aug. 2015
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.641
- Temp.:
- 25 °C
- pH:
- 6.95
Applicant's summary and conclusion
- Conclusions:
- Using the correlation log K / log POW, the log POW of the test substance Loperamide base (CAS 53179-11-6) was calculated as 2.641 ± 0.000 (mean ± standard deviation).
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