Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-416-5 | CAS number: 53179-11-6
Oxidising properties
Administrative data
- Endpoint:
- oxidising solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.17 (Oxidising Properties (Solids))
- GLP compliance:
- no
Test material
- Reference substance name:
- Loperamide
- EC Number:
- 258-416-5
- EC Name:
- Loperamide
- Cas Number:
- 53179-11-6
- Molecular formula:
- C29H33ClN2O2
- IUPAC Name:
- 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test item identification : 4-(4-clorofenil)-4-idrossi-N,N-dimetil-a,a-difenil-1--piperidinbutanamide
Purity : 99.7 % w/w
Expiry date : June 01, 2015
Constituent 1
Results and discussion
Test results (Oxidising solids)open allclose all
- Sample tested:
- 1:1 sample-to-cellulose ratio
- Parameter:
- burning rate
- Result:
- 0.37 mm/s
- Sample tested:
- 4:1 sample-to-cellulose ratio
- Parameter:
- burning rate
- Result:
- 0.1 mm/s
- Sample tested:
- 1:1 sample-to-cellulose ratio
- Parameter:
- burning time of reaction over a distance of 200 mm
- Result:
- 539 s
- Sample tested:
- 4:1 sample-to-cellulose ratio
- Parameter:
- burning time of reaction over a distance of 200 mm
- Result:
- 1 987 s
Any other information on results incl. tables
Preliminary Test
The test item was mixed with dried cellulose in the proportion 2 to 1 (w/w) and the mixture was formed into a small cone shaped pile of 3.5 cm (diameter of base) x 2.5 cm (height) by filling, without tamping, a cone-shaped former. The pile was then placed on a cool, non combustible, non-porous and low heat-conducting base plate.
The ignition source was applied to the cone and the test item was liquefied without vigorous reaction.
Reference substance mixture with cellulose
The barium nitrate reference substance was mixed with dried cellulose in various ratios and tested as described in the experimental section above.
The maximum burning rate of the reference substance was achieved with barium nitrate mixed with dried cellulose in the proportion 40 to 60 (% w/w).
Test item mixture with cellulose
The test item was mixed with dried cellulose in various ratios and tested as described in the experimental section.
Mixture Test item/cellulose (% w/w) Burning time Burning rate
over 200 mm (sec) (mm/sec)
A 10 / 90 334 0.60
B 20 / 80 336 0.59
C 30 / 70 338 0.52
D 40 / 60 453 0.44
E 50 / 50 539 0.37
F 60 / 40 658 0.30
G 70 / 30 747 0.27
H 80 / 20 1987 0.10
I 90 / 10 burning does not propagate -
From these preliminary results, the test item could have oxidizing properties.
However, these results could be a false positive since the test item is a not highly flammable
substance.
In order to investigate the possible false positive hypothesis, the tests with the three fastest
mixtures (A, B and C) were repeated using kieselguhr (diatomaceous earth) as an inert
support instead of the combustible cellulose. If the test item is a true oxidizing substance, the
burning rate would be slower as the test item has no material to oxidize.
The test repeated on the same ratios with the test item, using kieselguhr as an inert support,
showed no propagation of the flame.
The presence of the cellulose resulted important for the burning of mixtures and since the
maximum burning rate of the three fastest mixtures A, B and C (0.60 mm/sec) is lower than
the maximum burning rate of the reference mixture with barium nitrate and cellulose (40/60,
0.66 mm/sec), the test item is to be consider as a non oxidizing substance.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From the obtained experimental data according to the A.17 method in Council Regulation
(EC) No 440/2008 of 30 May 2008, it can be concluded that 4-(4-chlorophenyl)-4-hydroxy-
N,N-dimethyl-a,a-diphenyl sample is a non-oxidizing substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
