Registration Dossier
Registration Dossier
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EC number: 246-896-9 | CAS number: 25360-10-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The bioaccumulation potential for 1,1-dimethylheptanethiol has been read across from tert-dodecanethiol. Under the experimental conditions, tert-dodecanethiol had a biomagnification factor always lower than 0.01 and therefore dietary bioaccumulation was not observed.
Key value for chemical safety assessment
Additional information
The bioaccumulation potential of 1,1 -dimethylheptanethiol has been read across from tert-dodecanethiol, which was determined in a GLP-compliant study (Egeler et al 2013). One concentration of tert-dodecanethiol was prepared and the test animals were exposed to this concentration as well as to a negative control and a positive control treated with 14C-hexachlorobenzene for a test period of 15 days (uptake phase). Thereafter, the fish were fed on non-spiked fish food and a depuration phase of 42 days was performed. Although a standard guideline was not available for this test, the study took into account key aspects from the OECD 305 “bioconcentration: flow-through fish test”, the background document to the fish dietary study protocol and the OECD guideline “bioaccumulation in fish: aqueous and dietary exposure”.
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