Registration Dossier
Registration Dossier
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EC number: 234-499-3 | CAS number: 12007-16-8
Endpoint summary
Administrative data
Description of key information
The test substance was highly insoluble (2.6 µg/L) in a TD test conducted according to OECD 29 (see IUCLID section 4.8). Thus, the bioavailability of chromium, as the toxicological relevant part of the target substance, after administration to the skin can be expected to be very low.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The test substance was highly insoluble (2.6 µg/L) in a TD test conducted according to OECD 29 (see IUCLID section 4.8). Thus, the bioavailability of chromium, as the toxicological relevant part of the target substance, after administration to the skin can be expected to be very low. No information was found in the public domain, which would indicated any skin sensitising properties of chromium. Based on the results and in line with the 3R principles, the study is scientifically unjustified.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
