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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Comparative assessment of the effect produced on the organism by dust of borides and carbides of the transition metals, with special attention to the peculiarities of their electron structure
Author:
Brakhnova I.T.
Year:
1969
Bibliographic source:
Gig. Tr. Prof. Zabol. 13(1), 26-31.

Materials and methods

Principles of method if other than guideline:
Not specified. English abstract of Russian article available.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Details on test animals and environmental conditions:
Not specified. English abstract of Russian article available.

Administration / exposure

Details on study design:
Not specified. English abstract of Russian article available.

Results and discussion

Other findings:
Elevated fibrogenic action of borides (TiB2, ZrB2, CrB2) and dystrophy of liver, kidneys and sometimes myocardium compared to carbides. Toxic properties augmented parallel with decrement in the statistical wt. of stable d5 and sp3 electron configurations and an increased proportion of electrons in nonlocalized state.

Any other information on results incl. tables

Expts. on animals organisms for a comparative study on the effect of TiB2, ZrB2, and CrB2 as against amorphous B and metallic components of these borides were carried out. Analogously the effect of B4C, TiC, ZrC, and Cr2C, was studied. An elevated fibrogenic action and a more pronounced dystrophy of the liver, kidneys, and sometimes of the myocardium were found to take place under the effect of borides to a greater extent than under that of carbides. Toxic properties of the stated materials augmented parallel with decrement in the statistical wt. of stable d5 and sp3 electron configurations, forming themselves secondary to interaction of metallic and nonmetallic compds. and an increased proportion of electrons in nonlocalized state.

 

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Supporting information was available from an English abstract of a Russian publication, comparing the effect of TiB2, ZrB2, and CrB2 as against amorphous B and metallic components of these borides. Analogously the effect of B4C, TiC, ZrC, and Cr2C, was studied. An elevated fibrogenic action and a more pronounced dystrophy of the liver, kidneys, and sometimes of the myocardium were found to take place under the effect of borides to a greater extent than under that of carbides.
Executive summary:

A Russian publication is available comparing the effect of TiB2, ZrB2, and CrB2 as against amorphous B and metallic components of these borides. Analogously the effect of B4C, TiC, ZrC, and Cr2C, was studied. An elevated fibrogenic action and a more pronounced dystrophy of the liver, kidneys, and sometimes of the myocardium were found to take place under the effect of borides to a greater extent than under that of carbides. Toxic properties of the stated materials augmented parallel with decrement in the statistical wt. of stable d5 and sp3 electron configurations, forming themselves secondary to interaction of metallic and nonmetallic compds. and an increased proportion of electrons in nonlocalized state.

Based on the lacking information on study design and as only the abstract of this article is available in English, the publication was assigned with a Klimisch score of 4 and is used as supporting information, only.