Registration Dossier
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EC number: 232-259-2 | CAS number: 7803-49-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Acute toxic to fish
Key value for chemical safety assessment
Additional information
There are only a few publications available on the acute toxicity to fish. In a publication of the National Association of Photographic Manufactures (NAPM 1974) among other substances the effects of bis(hydroxylammonium)sulphate on Pimephales promelas were tested in a static system for 96 hours according to standard procedures outlined in Standard Methods, 13th Edition (ASTM, American Society for Testing and Materials). The LC50 determined in this test was 7.2 mg/l (corresponding to 2.9 mg/l hydroxylamine). Basic information about the test is given (dilution water was examined, daily monitoring of pH and dissolved oxygen was conducted). The study is carried out according to an old guideline and no concentrations were measured. Due to these facts, this study was considered as not reliable in EU-RAR draft 2008, however test results are consistent with results of other aqautic tests, as shown in this risk assessment and may therefore be taken into account in the aquatic hazard assessment.
In a publication from 1972 (Fletcher & Addison) about “some aspects of of the chemistry and acute toxicity of the iron ore flotation agent dimethyl ammonium alkyl hydroxamate and some related compounds to brook trout” lethal periods of DMAH and some related components were determined. The brook trout Salvelinus fontinalis was used as test organism. The high toxicity of hydroxylamine hydrochloride for fish was confirmed by an EC50 of 6 µl/l after 142 hours under flow-through conditions. In a parallel test for 80 hours of semi-static exposure the EC50 was 10 µl/l. However, not bis(hydroxylammonium)sulphate was tested. Hence the results are only of indicative value for this risk assessment.
Furthermore, in a static test, performed according to an old German guideline with only 48 hours test duration, an LC50 (48h) of 6.67 mg/l was observed for for Bis(hydroxylammonium)sulphate. However, due to insufficient documentation, the test is not valid. Nevertheless, since this result is in accordance with those of other studies, it may be used as supportive information.
In addition to that a screening report is available. In this study (Applegate et al. 1957) 4,346 chemicals were screened for their acute toxicity for rainbow trout, bluegill sunfish and sea lamprey for 24 hours of static exposure. The intention of the study was a screening for a substance toxic for lamprey but not toxic for fish. The study is not useful to determine effective concentrations.
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