Registration Dossier
Registration Dossier
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EC number: 231-953-2 | CAS number: 7782-40-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Due to diamond not being systemically available, toxicokinetics is not relevant.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Diamond, covalent cubic crystal structured carbon, is an inorganic solid with a high chemical inertness. It is completely inert against all known acids [1] and is insoluble in water (see section 4.8 of the IUCLID dossier) and organic solvents [2]. Due to diamond being insoluble in water (see section 4.8) and not containing intrinsically lipophilic functional groups, which would facilitate uptake across biological surfaces, uptake of diamond across biological membranes can be excluded. Furthermore, there is no indication for the presence of specific active transport systems which would be able to transport diamond through biological membranes into the blood stream or adipose tissue. Due to its physico-chemical characteristics it can be inferred that the substance is unlikely to be taken up into the blood stream, is not systemically available and not bioavailable. This is further supported by oral, inhalation and dermal studies conducted with diamond (see chapters 7.2.1, 7.2.2 and 7.2.3 of the IUCLID dossier). In standard OECD tests 423 and 402 diamond exhibited no acute orally toxic characteristics and no acute dermal toxic characteristics when applied to rats at a concentration of 2,000 mg/kg body weight. The negative results of an in vitro Cytotoxicity Assay (see section 7.12 of the IUCLID dossier) and the absence of cytotoxic effects in a pre-incubation test (Ames Test) with several Salmonella typhimurium strains (see section 7.6.1 of the IUCLID dossier) performed with an extract of diamond powder (200 g/L) underline the conclusion that diamond is not bioavailable (and not systemically available) due to its insolubility in water and fat. In addition, all ecotoxicological studies available for diamond showed no toxic characteristics of diamond indicating lack of uptake and absence of systemical availability.
Due to diamond not being systemically available, toxicokinetics is not relevant.
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