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Diss Factsheets
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EC number: 231-953-2 | CAS number: 7782-40-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Due to diamond not being systemically available, toxicokinetics is not relevant.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Diamond, covalent cubic crystal structured carbon, is an inorganic solid with a high chemical inertness. It is completely inert against all known acids [1] and is insoluble in water (see section 4.8 of the IUCLID dossier) and organic solvents [2]. Due to diamond being insoluble in water (see section 4.8) and not containing intrinsically lipophilic functional groups, which would facilitate uptake across biological surfaces, uptake of diamond across biological membranes can be excluded. Furthermore, there is no indication for the presence of specific active transport systems which would be able to transport diamond through biological membranes into the blood stream or adipose tissue. Due to its physico-chemical characteristics it can be inferred that the substance is unlikely to be taken up into the blood stream, is not systemically available and not bioavailable. This is further supported by oral, inhalation and dermal studies conducted with diamond (see chapters 7.2.1, 7.2.2 and 7.2.3 of the IUCLID dossier). In standard OECD tests 423 and 402 diamond exhibited no acute orally toxic characteristics and no acute dermal toxic characteristics when applied to rats at a concentration of 2,000 mg/kg body weight. The negative results of an in vitro Cytotoxicity Assay (see section 7.12 of the IUCLID dossier) and the absence of cytotoxic effects in a pre-incubation test (Ames Test) with several Salmonella typhimurium strains (see section 7.6.1 of the IUCLID dossier) performed with an extract of diamond powder (200 g/L) underline the conclusion that diamond is not bioavailable (and not systemically available) due to its insolubility in water and fat. In addition, all ecotoxicological studies available for diamond showed no toxic characteristics of diamond indicating lack of uptake and absence of systemical availability.
Due to diamond not being systemically available, toxicokinetics is not relevant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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