Registration Dossier
Registration Dossier
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EC number: 230-022-8 | CAS number: 6915-15-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Activated sludge respiration inhibition: >300 mg/L
Key value for chemical safety assessment
- EC50 for microorganisms:
- 300 mg/L
Additional information
Activated sludge obtained from a sewage treatment plant was exposed in a 3 -hour respiration inhibition test to fumaric acid.The 3 -hour EC50 based on respiration inhibition was >300 mg fumaric acid/L.
Read across to fumaric acid is considered valid and malic acid is considered to exhibit similar low toxicity. The rational for read across is that fumaric acid will metabolise in biological systems to malic acid. Fumaric acid is also slightly more fat soluble and is considered more likely to absorb via membranes and increase transport.
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