Registration Dossier
Registration Dossier
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EC number: 210-545-8 | CAS number: 618-36-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
The inhibiting effect of DL-alpha-methylbenzylamine (CAS 618 -36 -0) is assessed via a read-across approach to short-term respiration inhibition studies of two structurally similar substances (L-alpha-methylbenzylamine, CAS 2627 -86 -3; D-alpha-methylbenzylamine, CAS 3886 -69 -9). Both studies followed OECD 209 and used activated sludges from a laboratory wastewater treatment plant using municipal and synthetic sewage. In both cases, the 30-min EC20 was determined to be greater than 100 mg/L indicating that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
- L-alpha-methylbenzylamine (CAS 2627-86-3) 30-min EC20: ca. 600 mg/L; 30 -min EC50: > 1000 mg/L (BASF AG, 1998; report no. 98/0321/08/1)
- D-alpha-methylbenzylamine (CAS 3886-69-9): 30-min EC20: ca. 550 mg/L; 30 -min EC50: > 1000 mg/L (BASF AG, 1998; report no. 98/0320/08/1)
Results of a growth inhibition test with Tetrahymena pyriformis support these findings that the microbial toxicity is low (Schultz et al., 2003, 40 -h IC50 = 184 mg/L). According to the REACH Guidance R.10, test results from a short-term respiration study are to be preferred for the derivation of the PNEC.
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