Registration Dossier
Registration Dossier
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EC number: 206-200-6 | CAS number: 307-35-7
Endpoint summary
Administrative data
Description of key information
For PFOS, similar toxic effects are produced in subchronic studies in rats and monkeys. These effects are generally characterized as body-weight or body-weight gain decreases, liver-weight orelative liver-weight increases, liver cell hypertrophy, in some cases with vacuolation, and a reduction in serum cholesterol levels.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- Study duration:
- subchronic
Additional information
For PFOS, similar toxic effects are produced in subchronic studies in rats and monkeys. These effects are generally characterized as body-weight or body-weight gain decreases, liver-weight orelative liver-weight increases, liver cell hypertrophy, in some cases with vacuolation, and a reduction in serum cholesterol levels.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver
Justification for classification or non-classification
Perfluoroctanesulfonyl fluoride is a salt of PERFLUOROOCTANE SULFONIC ACID.
Available studies of PERFLUOROOCTANE SULFONIC ACID are used to classify the PERFLUOROOCTANE SULFONIC ACID following a category approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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