Registration Dossier
Registration Dossier
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EC number: 205-126-1 | CAS number: 134-03-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justicifation, please refer to attached read across justification in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 020 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Reference
Description of key information
The LC50 of the analogue substance was determined to be 1020 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 020 mg/L
Additional information
No experimental data on toxicity to fish are available for the substance itself. Therefore, the toxic potential to fish was assessed based on data available for the close structural analoque ascorbic acid (CAS 50-81-7).
To asssess the acute toxicity of the close structural analogue to fish, a GLP-compliant study according to OECD Guideline 203 (May 1981) was carried out. Based on results of a preliminary study, groups of 10 rainbow trouts (Onchorhynchus mykiss) were exposed to nominal concentrations of 400, 600, 800, 1000 and 1200 mg/L. A negative control without the test item ran in parallel. Since the pH of the test water was changed markedly after addition of the test item, an additional test was conducted, using three concentrations of 600, 800 and 1000 mg/L and adjusting the pH with NaOH to 7.5 +/- 0 .5. The maintenance of the test item (> 80% during the test) was confirmed by DOC analysis. In result, the 96-h LC50 of the test item was determined to be 1020 mg/L (nominal, derived from raw data of the first test without adjustment of pH). The LC 100 was 1200 mg/L (nominal, based on results of the first test) and the NOEC was 800 mg/L (nominal, based on results of the second test with adjustment of pH).
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