Registration Dossier
Registration Dossier
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EC number: 204-683-8 | CAS number: 124-13-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
One (reliable with restrictions) study has been provided. The aim of this study was to determine the acute lethal toxicity (14 day LC50) of several aliphatic and cyclic aldehydes to the guppy and to describe the toxicity of these compounds through the use of quantitative structure-activity relationships.
The 14 day LC50 of octanal was determined in a semi-static experiments with renewal of the test solutions daily. Poecilia reticulata were exposed to at least 5 concentrations, geometrically increasing with a factor of 1.8. Ten fish were exposed to each concentration.
The reactivity of the tested aldehydes was assesssed using cysteine as the opposing nucleophile. The degree of reaction between the aldehyde and cysteine after 1 min. of mixing equimolar amounts of both reagents was used as a measure of the aldehydes reactivity.
The 14 -day LC50 for octanal was found to be 1.79 µmoles/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.9 mg/L
Additional information
The aim of this study was to determine the acute lethal toxicity (14 day LC50) of several aliphatic and cyclic aldehydes to the guppy and to describe the toxicity of these compounds through the use of quantitative structure-activity relationships. The 14 day LC50 of octanal was determined in a semi-static experiments with renewal of the test solutions daily. Poecilia reticulata were exposed to at least 5 concentrations, geometrically increasing with a factor of 1.8. The 14 -day LC50 for octanal was found to be 1.79 µmoles/L.
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