Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-411-8 | CAS number: 120-61-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Two reliable (Klimisch 2/1, guideline- and GLP-compliant) studies address the short-term toxicity of dimethyl terephthalate to freshwater fish.
In the first study (Anonymous, 1994), zebra fish (Danio rerio) were exposed to high purity DMT, dosed from a saturated aqueous stock solution. The highest achievable, dissolved exposure concentration was 36 mg DMT/L.
Zebra fish (D. rerio) 96 -h LC50 (semi-static): 13 mg DMT/L, 96 -h NOEC: 9.6 mg DMT/L.
These endpoints are mean measured values based on non-specific analyses of organic carbon (OC). Based on evidence of hydrolytic stability for >24 h in other studies, it is assumed that DMT remained substantially intact under the semi-static media renewal regime employed in this study.
In the second study (Government of Japan, Ministry of the Environment, 2002a) himedaka (Oryzias latipes) were exposed to high purity DMT, dosed from a stock solution prepared with THF. No toxicity was observed under these test conditions:
Himedaka (O. latipes) 96 -h LC50 (semi-static): >5.37 mg DMT/L, 96 -h NOEC: 5.37 mg DMT/L.
These endpoints are mean measured values and represent the maximum limit concentration achievable under the test conditions with the dosing regime employed.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 13 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
