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EC number: 204-200-0 | CAS number: 117-61-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- The prediction done by using QSAR Toolbox version 3.1
- GLP compliance:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- Unspecified
- Frequency of treatment:
- no data
- No. of animals per sex per dose:
- no data
- Dose descriptor:
- other: not specified
- Based on:
- other: not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Dose descriptor:
- LOEL
- Generation:
- F2
- Effect level:
- 1 171.775
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- The lowest observed effect level (LOEL) in Rat F2 generation male/female; as predicted by the QSAR model was found to be 1171.77mg/kg/day. Thus, it can be concluded that below this dose level benzidine-2,2'-disulphonic acid shall not exhibit reproductive toxicity to the male and female rats
- Executive summary:
The lowest observed effect level (LOEL) in Rat F2 generation male/female; as predicted by the QSAR model was found to be 1171.77mg/kg/day. Thus, below this dose level it can be concluded that benzidine-2,2'-disulphonic acid shall not exhibit reproductive toxicity to the male and female rats
Reference
The
prediction was based on dataset comprised from the following
descriptors: LOEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a"
and ("b"
and (
not "c")
)
)
and "d" )
and ("e"
and "f" )
)
Domain
logical expression index: "a"
Similarity
boundary:Target:
c1(-c2c(S(=O)(=O)O)cc(N)cc2)c(S(=O)(=O)O)cc(N)cc1
Threshold=50%,
Dice(Atom pairs)
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR SN2 OR SN2 >> SN2 reaction at a
sp2 carbon atom OR SN2 >> SN2 reaction at a sp2 carbon atom >> Polarised
alkenes with a halogen leaving group OR SN2 >> SN2 reaction at sp3
carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Allyl acetates
and related chemicals OR SN2 >> SN2 reaction at sp3 carbon atom >>
Thiophosphates by Protein binding by OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis
Domain
logical expression index: "e"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -3.64
Domain
logical expression index: "f"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.0327
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Since the QSAR model is considered reliable by OECD, the prediction is expected to be reliable
Additional information
Short description of key information:
Toxicity to reproduction
The lowest observed effect level (LOEL) in Rat F2 generation male/female; as predicted by the QSAR model was found to be 1171.77mg/kg/day. Thus, it can be concluded that below this dose level benzidine-2,2'-disulphonic acid shall not exhibit reproductive toxicity to the male and female rats
Justification for selection of Effect on fertility via oral route:
QSAR model considered reliable by OECD
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
