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EC number: 203-816-7 | CAS number: 110-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity (similar to OECD TG 401): LD50 = 3570 mg/kg bw
Acute dermal toxicity (non-guideline study): LD50 >5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Study was performed acc. internal BASF method, which was in part equivalent to OECD Guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: average 172 g (females) and 194 g (males) - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 16, and 30%
- Amount of vehicle (if gavage): 10 ml/kg bw
- Other: vehicle solution contained 2-3 drops of cremophor EL (as solubilizer) - Doses:
- 0.2, 1.6, 3.2, 4.0, 5.0 and 6.4 ml/kg bw = (calculated with density of 0.85 at 20 °C): 170, 1360, 2720, 3400, 4250 and 5540 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 570 mg/kg bw
- Mortality:
- 5540 mg/kg bw: 5/5 males and 4/5 females died within 24 hrs, 1 additional female died within 7 days 4250 mg/kg bw: 4/5 males and 2/5 females died within 24 hrs 3400 mg/kg bw: 0/5 males and 0/5 females died within 7 days 2720 mg/kg bw: 0/5 males and 1/5 females died within 24 hrs 1360 mg/kg bw: 2/5 males and 0/5 females died within 24 hrs 170 mg/kg bw: 0/5 males and 0/5 females died within 7 days
- Clinical signs:
- other: 5540 mg/kg bw: Abdominal and lateral position, atonia, apathy, severe dyspnoea 4250 - 1360 mg/kg bw: abdominal position, apathy, atonia, gasping, smeared fur, animals were without clinical symptoms after 5 days 170 mg/kg bw: atonia, gasping, after 1 day
- Gross pathology:
- In animals that died due to substance application: 5540 - 1360 mg/kg bw: acute heart dilatation, congestive hyperemia; greyish discoloration of liver and kidneys In animals that were sacrificed after post observation period: No abnormalities detected in any group
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP Criteria
- Conclusions:
- Under the conditions of the test, the oral LD50 was determined to be 3570 mg/kg bw. Therefore, the substance does not need to be classified for acute toxicity in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
An acute oral fixed dose study was performed, according to a internal BASF method, which was in part equivalent to OECD Guideline 401. Sprague Dawley (Gassner) rats, 5 male and 5 female per dose, were exposed to doses of 170, 1360, 2720, 3400, 4250 and 5540 mg/kg bw (density at 200C of 0.85 g/ml) by oral gavage. Animals were observed for 7-days after dosing, all symptoms and deaths were recorded. Necropsy was performed in animals that died due to substance application. Under the conditions of the test, the oral LD50 was estimated to be ca. 3570 mg/kg bw after 7 days for males and females.
This present data on acute oral toxicity is > 2000 mg/kg bw, therefore, the substance does not need to be classified for acute toxicity in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 570 mg/kg bw
- Quality of whole database:
- Key study is comparable to guideline study with acceptable restrictions.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study with limited documentation from secondary source which meets basic scientific principles.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute dermal toxicity test in rabbits
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: mortality and clinical signs - Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- 1/6 deaths occurred on day 9
- Interpretation of results:
- other: not classified
- Remarks:
- based on CLP criteria
- Conclusions:
- Under the conditions of the test, the dermal LD50 was > 5000 mg/kg bw. Therefore, the substance does not need to be classified for acute toxicity in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
An acute dermal toxicity study was performed. Duration of observation period following administration: 14 days, mortality and clinical signs were examined.
Under the conditions of the test, the dermal LD50 was > 5000 mg/kg bw. Therefore, the criteria laid down in Annex I of the CLP Regulation (1272/2008/EC) are not fullfilled and the substance does not need to be classified for acute toxicity.
Reference
The present data on acute dermal toxicity do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The key study is an acceptable study with limited documentation from secondary source which meets basic scientific principles.
Additional information
Acute oral toxicity
An acute oral fixed dose study was performed, according to a internal BASF method, which was in part equivalent to OECD Guideline 401. Sprague Dawley (Gassner) rats, 5 male and 5 female per dose, were exposed to doses of 170, 1360, 2720, 3400, 4250 and 5540 mg/kg bw (density at 200C of 0.85 g/ml) by oral gavage. Animals were observed for 7-days after dosing, all symptoms and deaths were recorded. Necropsy was performed in animals that died due to substance application. Under the conditions of the test, the oral LD50 was estimated to be ca. 3570 mg/kg bw after 7 days for males and females.
Acute dermal toxicity
An acute dermal toxicity study was performed. Duration of observation period following administration: 14 days, mortality and clinical signs were examined.
Under the conditions of the test, the dermal LD50 was >5000 mg/kg bw.
Justification for classification or non-classification
Based on the available data, Methylheptenone does not need to be classified for acute oral and dermal toxicity in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
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