Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-839-4 | CAS number: 75-10-5
Endpoint summary
Administrative data
Description of key information
In accordance to section 2 of REACH Annex XI, the study does not need to be conducted as the substance is a gas. The gaseous nature of difluoromethane precludes the conductance of conventional skin and eye irritation studies in animals. However, acute exposure up to 520,000 ppm (1107000 mg/m3) and repeated exposure up to 50,000 (105000 mg/m3) ppm did not show signs of eye, skin or respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In accordance to section 2 of REACH Annex XI, the studies on skin and eye irritation do not need to be conducted as the substance is a gas.
Justification for classification or non-classification
The gaseous nature of difluoromethane precludes the conduct of conventional skin and eye irritation tests in animals. Therefore, classification for skin and eye irritation is not applicable according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
