Registration Dossier
Registration Dossier
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EC number: 200-521-5 | CAS number: 61-82-5
Endpoint summary
Administrative data
Description of key information
Skin irritation: Not irritating (OECD 404, GLP, Rel.2, K).
Eye irritation: Not irritating (OECD 405, GLP, Rel. 2, K).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
A key study was identified (CIT, 2001, rel. 2). This dermal irritation study was performed according to the OECD Guideline No. 404, and in compliance with GLP.
A very slight erythema was noted in all animals on Day 1; it persisted up to Day 2 in one animal and up to Day 3 in another one. No other cutaneous reactions were observed.
The individual scores for each animal within 3 scoring times (24, 48 and 72 h) were 0.7 / 0.0 / 0.3 for erythema and 0.0 / 0.0 / 0.0 for oedema
Eye irritation:
A key study was identified (CIT, 2002, Rel. 2). This eye irritation study was performed according to the OECD Guideline No. 405, and in compliance with GLP.
No corneal or iridial effects were noted during the study. Conjunctivae redness (grade 1) was noted in all animals at 1 hour after exposure; completely reversible within 24 hours. No other ocular reactions were observed.
Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals were 0.0 / 0.0 / 0.0 for cornea score; 0.0 / 0.0 / 0.0 for iris score; 0.0 / 0.0 / 0.0 for conjunctivae score and 0.0 / 0.0 / 0.0 for chemosis score.
Justification for classification or non-classification
Harmonized classification:
The substance has no harmonized classification for irritation or corrosion according to the Regulation (EC) No. 1272/2008.
Self classification:
Based on the available data no additional self-classification is proposed regarding both skin and eye irritation according to the Annex VI of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
No data was available regarding respiratory irritation, however the substance not being classified for skin and eye irritation, no classification is expected for respiratory irritation.
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