Registration Dossier
Registration Dossier
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EC number: 200-466-7 | CAS number: 60-27-5
Endpoint summary
Administrative data
Description of key information
Additional information
Appearence / physical state / colour:
The substance Creatinine is a colourless and odourless solid.
Melting point / freezing point:
A melting point of 305 °C (with decomposition) for Creatinine is reported by RÖMPP Lexikon Chemie.
Boiling point:
In accordance with REACH Annex VII, column 2, the study does not need to be conducted because Creatinine decomposes before boiling.
Density:
The density of Creatinine (CAS 60-27-5) has been determined to be 1.39 x 10^3 kg/m3 at 20.3 ± 0.5 °C (relative density: 1.39), using a gas comparison pycnometer.
Particle size distribution (Granulometry):
The median value of particle size of Creatinine is 73.96 µm.
Vapour pressure:
In accordance with REACH Annex VII, column 2, the study does not need to be conducted if the melting point of the substance is above 300 °C. Creatinine decomposes before boiling at a temperature of 305 °C. Therefore it is not necessary to perform this study.
Partition coefficient:
The partition coefficient of Creatinine was published as experimental result in Estimated Programs Interface (EPI) Suite TM, US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC):
Log Kow = -1.76
This value was confirmed by different QSAR calculations. The partition coefficient of Creatinine was calculated to be -1.77 (EPISuite), -1.29 (Multicase) and -074 (Vega).
Therefore a log Kow = -1.76 was considered for all further evaluations.
Water solubility:
A water solubility of 90 g/L (20 °C) for Creatinine is reported by RÖMPP Lexikon Chemie.
Surface tension:
In accordance with REACH Annex VII, column 2, the study needs only be conducted if surface activity is a desired property of the material. Surface activity is not a desired property of Creatinine.
Flash point:
In accordance with REACH Annex XI the study does not need to be conducted as Creatinine is solid. The flash point is a key measure of the flammability of a liquid. It measures the lowest temperature at which the vapour /air mixture above the liquid can be ignited.
Auto flammability:
Two tests for dusty Creatinine are available evaluating the auto-flammability on a hot surface for deposited and dispersed Creatininine. No auto-ignition of deposited Creatinine dust occurred on surfaces until 360°C. Also no-auto-ignition of dispersed Creatinine dust was observed until 600 °C.
Flammability:
Creatinine can be ignited but it is melting and burning off calmly. Therefore Creatinine is considered to be not highly flammable.
Explosivness:
The mechanical sensitivity (shock and friction) of the test substance according to a test method similar to guideline EU A.14 was determined. The tests for mechanical sensitivity to friction and shock showed no explosive properties of Creatinine.
Oxidising properties:
In accordance with REACH Annex VII, column 2, the study does not need to be conducted as the substance Creatinine does not contain halogen atoms. The oxygen atoms are not chemically bonded to nitrogen. Therefore, the substance is considered incapable of reacting exothermically with combustible materials.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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