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Diss Factsheets
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EC number: 200-466-7 | CAS number: 60-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Due to legal reasons it is not justified to perform this studies.
The substance is used solely for cosmetic uses. According to Directive 76/768/EEC (Cosmetics Directive) and in Regulation 1223/2009/EC (Cosmetics Regulation) it is not allowed to perform animal tests, although cosmetic raw materials are subject to restriction (marketing ban). Therefore the test on acute oral toxicity has to be waived.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Due to legal reasons it is not justified to perform this studies. The substance is used solely for cosmetic uses. According to Directive 76/768/EEC (Cosmetics Directive) and in Regulation 1223/2009/EC (Cosmetics Regulation) it is not allowed to perform animal tests, although cosmetic raw materials are subject to restriction (marketing ban). Therefore the test on acute oral toxicity has to be waived.
Justification for selection of acute toxicity – oral endpoint
Due to legal reasons it is not justified to perform this study. The
substance is used solely for cosmetic uses. According to Directive
76/768/EEC (Cosmetics Directive) and in Regulation 1223/2009/EC
(Cosmetics Regulation) it is not allowed to perform animal tests,
although cosmetic raw materials are subject to restriction (marketing
ban). Therefore the test on acute oral toxicity has to be waived.
Justification for classification or non-classification
Creatinine is an endogenous substance. Creatinine is a breakdown product of Creatine in muscle and is usually produced at a fairly constant rate by the body (depending on muscle mass). According to “Wissenschaftliche Tabellen, 7. Auflage, 1969, J.R. Geigy S.A., Basel, Schweiz” considerable amounts of Creatinine can be found in the different compartments and body fluids:
Cord blood plasm or serum: 11.8 mg/L (6.4 – 17.2 mg/L)
Blood plasm or serum, child (4-21 weeks): 9.5 mg/L (7.9 – 11.1 mg/L)
Blood plasm or serum, child (1-6 years): 11.9 mg/L (7.5 -16.3 mg/L)
Blood plasm or serum, adult:12.4 mg/L (6.6 – 18.2 mg/L)
Liquor cerebrospinalis: 6-14 mg/L
Gastric juice: 12-33 mg/L
Urine, male (20-45 years): 1.8 (1.2 - 2.5 g/24h)
Urine, female (20-45 years): 1.17 (0.01 - 1.33 g/24h)
Sweat: 4.6 mg/L (2.1 - 8.4 mg/L)
Mother’s milk: 11 mg/L (8 - 19 mg/L)
Furthermore Creatinine is part of the diet and can be found in lean meat in constant content of 0.02 – 0.04 % (G.Mayer, H.Knapp, RÖMPP, Thieme Verlag, 2009).
Therefore it can be assumed that Creatinine is not a toxic substance and should not be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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