Ethyl 2-methyl-1,3-dioxolane-2-acetate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not reported

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

0.8

Temp.:

35 °C

Remarks on result:

other: The determination was performed at 35 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature.

Details on results:

The determination was performed at 35 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.

tR1, tR2: tRm : retention times (1st calibration, 2nd calibration, average)

k = (tR/t0)-1 : capacity factor, t0: "dead time", i.e, retention time of thiourea

reference substance	log Pow	tR1	tR2	tRm	k	log k
thiourea		1.79	1.79	1.79
aniline	0.9	2.71	2.71	2.71	0.510	-0.293
methyl benzoate	2.1	3.62	3.62	3.62	1.021	0.009
benzophenone	3.2	5.06	5.06	5.06	1.823	0.261
1,2,4 -trichlorobenzene	4.2	9.07	9.07	9.07	4.056	0.608
n-butylbenzene	4.6	11.17	11.17	11.17	5.231	0.719
triphenylamine	5.7	18.25	18.25	18.25	9.179	0.963

Linear regression parameters : Log Pow = a . log k + b

Correlation coefficient : r² = 0.99319

Slope : a = 3.70533

Y-axis intercept : b = 2.07943

TEST MATERIAL

tR1= 2.619

tR2= 2.619 -> tRm= 2.619

k= 0.461

log k= -0.337 ->log Pow=0.8

Conclusions:

Under the conditions of the study the log Pow of the test material was determined to be 0.8.

Executive summary:

The partition coefficient of the test material was determined in a GLP study which was conducted according to the standardised guideline OECD 117 following the HPLC method. Under the conditions of the study the log Pow of the test material was determined to be 0.8.

Description of key information

Log Kow: 0.8 at 35°C

Key value for chemical safety assessment

Log Kow (Log Pow):

0.8

at the temperature of:

35 °C