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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1967
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, study predating OECD guideline, but scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report date:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
Principles of method if other than guideline:
BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-(morpholin-4-yl)ethan-1-ol

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.0 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
1, 5, 15 min
20 h
Observation period:
8 days
Number of animals:
2 males
Details on study design:
TEST SITE
- Area of exposure: Back (2.5 x 2.5 cm) and ear

SCORING SYSTEM: Draize scoring system. Results originally reported according to BASF scoring system and transformed to scores according to OECD guideline 404.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24/48 h
Score:
1.5
Max. score:
4
Reversibility:
fully reversible within: 8 d
Remarks on result:
other: application time 20 h
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24/48 h
Score:
1.5
Max. score:
4
Reversibility:
fully reversible within: 8 d
Remarks on result:
other: application time 20 h
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24/48 h
Score:
0
Max. score:
4
Remarks on result:
other: application time 20 h
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24/48 h
Score:
0
Max. score:
4
Remarks on result:
other: application time 20 h
Irritant / corrosive response data:
No signs of irritation were observed in two animals after 1, 5 and 15 min exposure on the back. Slight redness was observed in both animals after 24 and 48 h (ear and back) when treated for 20 h. The irritation was reversible within 8 days.
Other effects:
none

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Classification: not irritating